Description

2,4-Dichloro-5-iodopyridine (CAS No. 343781-49-7) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂Cl₂IN. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both chloro and iodo substituents on the pyridine ring, enables selective functionalization for the development of complex heterocyclic compounds. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a crystalline solid under inert packaging to maintain stability. Ideal for Suzuki couplings, nucleophilic substitutions, and metal-catalyzed cross-coupling reactions.

Key Features:

• IUPAC Name: 2,4-dichloro-5-iodopyridine
• CAS: 343781-49-7 | EC: 866-406-2
• Molecular Weight: 273.89 g/mol
• Storage: 2-8°C under nitrogen
• Hazard Codes: H302-H315-H319-H335

Properties

• CAS Number: 343781-49-7
• Complexity: 101
• IUPAC Name: 2,4-dichloro-5-iodo-pyridine
• InChI: InChI=1S/C5H2Cl2IN/c6-3-1-5(7)9-2-4(3)8/h1-2H
• InChI Key: BXGGIBSWLOTEPO-UHFFFAOYSA-N
• Exact Mass: 272.86090
• Molecular Formula: C5H2Cl2IN
• Molecular Weight: 273.88
• SMILES: C1=C(C(=CN=C1Cl)I)Cl
• Topological: 12.9
• Monoisotopic Mass: 272.86090
• Synonyms: 2,4-dichloro-5-iodopyridine, 343781-49-7, DTXSID80441518, DTXCID80392339, 866-406-2, MFCD09033755, 2,4-dichloro-5-iodo-pyridine, 5-Iodo-2,4-dichloropyridine, SCHEMBL16997464, BBL102011, STL555810, 2 pound not4-Dichloro-5-iodopyridine, AKOS015889462, CS-W021506, DS-18361, SY037731, DB-068978, F19994

Application

2,4-Dichloro-5-iodopyridine serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Its reactivity at the 2, 4, and 5 positions allows for sequential modifications, making it valuable in constructing kinase inhibitors and antimicrobial agents. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to introduce pyridine motifs into complex molecules. It is also employed in material science for developing functionalized ligands in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

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