Description

2,4-Dibromo-1-fluorobenzene (CAS No. 1435-53-6) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃Br₂F. This organofluorine building block features two bromine substituents at the 2- and 4-positions and a fluorine at the 1-position of the benzene ring, offering unique reactivity for electrophilic aromatic substitution and metal-catalyzed coupling reactions. Provided as a crystalline solid with ≥98% purity (GC), it is ideal for pharmaceutical intermediates, agrochemical synthesis, and materials science research. Packaged under inert gas in amber glass vials to ensure stability, this compound is characterized by ¹H/¹³C NMR, GC-MS, and elemental analysis. Handle with appropriate PPE in well-ventilated areas due to halogenated compound hazards.

Properties

• CAS Number: 1435-53-6
• Complexity: 97.1
• IUPAC Name: 2,4-dibromo-1-fluoro-benzene
• InChI: InChI=1S/C6H3Br2F/c7-4-1-2-6(9)5(8)3-4/h1-3H
• InChI Key: MKHDDTWHDFVYDQ-UHFFFAOYSA-N
• Exact Mass: 253.85650
• Molecular Formula: C6H3Br2F
• Molecular Weight: 253.89
• SMILES: C1=CC(=C(C=C1Br)Br)F
• Monoisotopic Mass: 251.85855
• Synonyms: 2,4-Dibromo-1-fluorobenzene, 1435-53-6, EINECS 215-860-4, DTXSID70162447, NSC 88308, DTXCID5084938, 215-860-4, 1,3-Dibromo-4-fluorobenzene, 2,4-DIBROMOFLUOROBENZENE, 1-Fluoro-2,4-dibromobenzene, Benzene, 2,4-dibromo-1-fluoro-, MFCD00000283, 8Q9HP36PKV, NSC-88308, 2,4-dibromo-1-fluoro-benzene, NSC88308, UNII-8Q9HP36PKV, NCIOpen2_005346, Benzene,4-dibromo-1-fluoro-, SCHEMBL321812, SCHEMBL23531196, SBB101338, 2,4-Dibromo-1-fluorobenzene, 90%, AKOS005762928, AC-9699, CS-W010191, AS-14421, SY038233, DB-042694, D3489, NS00044653, ST50408614, EN300-53154, A20822, 2,4-Dibromo-1-fluorobenzene, technical grade, 70%, InChI=1/C6H3Br2F/c7-4-1-2-6(9)5(8)3-4/h1-3, Benzene, 2,4-dibromo-1-fluoro-;1,3-Dibromo-4-fluorobenzene, tech;1,3-Dibromo-4-fluorobenzene

Application

2,4-Dibromo-1-fluorobenzene serves as a versatile precursor in Suzuki-Miyaura and Ullmann coupling reactions to synthesize biaryl compounds for liquid crystal materials. Its electron-deficient aromatic ring facilitates nucleophilic substitution in pharmaceutical intermediates, particularly for fluorinated drug candidates. Researchers also employ it as a scaffold for developing flame retardants and halogenated organic semiconductors.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.