Description

(2,3,4-Trifluorophenyl)methanol (CAS No. 144284-24-2) is a high-purity fluorinated benzyl alcohol derivative with the molecular formula C₇H₅F₃O. This specialized organic compound features a trifluorinated phenyl ring with a hydroxymethyl functional group, making it a valuable intermediate in pharmaceutical, agrochemical, and materials science research. Its unique fluorine substitution pattern enhances its utility in designing bioactive molecules, liquid crystals, and advanced polymers. Available in >98% purity (HPLC/GC), this product is supplied in rigorously tested vials under inert gas to ensure stability and shelf life. Ideal for nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for fluorinated ligands or catalysts. MSDS and analytical certificates provided.

Properties

• CAS Number: 144284-24-2
• Complexity: 131
• IUPAC Name: (2,3,4-trifluorophenyl)methanol
• InChI: InChI=1S/C7H5F3O/c8-5-2-1-4(3-11)6(9)7(5)10/h1-2,11H,3H2
• InChI Key: LOZFHOHUIYBNCJ-UHFFFAOYSA-N
• Exact Mass: 162.02924926
• Molecular Formula: C7H5F3O
• Molecular Weight: 162.11
• SMILES: C1=CC(=C(C(=C1CO)F)F)F
• Topological: 20.2
• Monoisotopic Mass: 162.02924926
• Synonyms: 144284-24-2, (2,3,4-trifluorophenyl)methanol, DTXSID20380336, DTXCID60331362, 639-358-3, 2,3,4-Trifluorobenzyl alcohol, Benzenemethanol, 2,3,4-trifluoro-, (2,3,4-trifluorophenyl)methan-1-ol, 2,3,4-trifluorobenzylalcohol, MFCD00083551, SCHEMBL698604, SCHEMBL982698, SCHEMBL16957327, LOZFHOHUIYBNCJ-UHFFFAOYSA-N, SBB087571, AKOS009158517, AC-12998, PS-10187, DB-001200, CS-0195146, ST50407434, EN300-129721, Z1183459266

Used as a key synthon in pharmaceutical development, particularly for fluorinated drug candidates targeting CNS and antimicrobial applications. Employed in liquid crystal formulations for display technologies due to its polar fluorinated structure. Also serves as a building block for specialty polymers with enhanced thermal/chemical resistance. Compatible with Pd-catalyzed coupling reactions for complex aryl-fluorine architectures.

Safety and Hazards

GHS Hazard Statements

• H301 (20%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (80%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (20%)
• Skin Irrit. 2 (80%)
• Eye Irrit. 2A (80%)
• STOT SE 3 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.