Description

Description

2,3,4-Trifluorobenzonitrile (CAS No. 143879-80-5) is a high-purity fluorinated aromatic nitrile compound with the molecular formula C₇H₂F₃N. This specialty chemical is characterized by its trifluorinated benzene ring and reactive cyano (-CN) group, making it a versatile building block for pharmaceutical, agrochemical, and materials science applications. The compound is supplied as a clear to pale-yellow liquid or low-melting solid with a purity of ??97% (GC), packaged under inert gas to ensure stability. Its unique electronic properties derived from the fluorine substitution pattern enable selective reactivity in cross-coupling reactions, nucleophilic aromatic substitutions, and cyclization processes. Researchers value this compound for its role in synthesizing fluorinated heterocycles and active pharmaceutical ingredients (APIs), particularly in CNS drug development. Technical specifications include: molecular weight 163.09 g/mol, density ~1.4 g/cm³, and storage recommendations of 2-8??C in amber glass containers.

Application

2,3,4-Trifluorobenzonitrile serves as a key intermediate in the synthesis of fluorinated liquid crystals for advanced display technologies. The compound’s electron-deficient aromatic system facilitates palladium-catalyzed cross-coupling reactions to create novel bioactive molecules in medicinal chemistry. Its trifluorinated structure is particularly valuable for developing PET radiotracers and CNS-targeting pharmaceuticals due to enhanced blood-brain barrier penetration.

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