Description

2,3,4-Trifluoroaniline (CAS No. 3862-73-5) is a high-purity fluorinated aromatic amine with the molecular formula C₆H₄F₃N. This compound is a versatile building block in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and advanced materials. Its trifluorinated structure enhances reactivity and stability, making it ideal for nucleophilic substitution reactions and cross-coupling methodologies. Available in >98% purity (GC), this product is rigorously tested for consistency and suitability in sensitive applications. Packaged under inert gas to prevent degradation, it is supplied in amber glass bottles or custom bulk quantities to meet industrial demands.

Properties

• CAS Number: 3862-73-5
• Complexity: 120
• IUPAC Name: 2,3,4-trifluoroaniline
• InChI: InChI=1S/C6H4F3N/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2
• InChI Key: WRDGNXCXTDDYBZ-UHFFFAOYSA-N
• Exact Mass: 147.02958362
• Molecular Formula: C6H4F3N
• Molecular Weight: 147.10
• SMILES: C1=CC(=C(C(=C1N)F)F)F
• Topological: 26
• Monoisotopic Mass: 147.02958362
• Synonyms: 2,3,4-Trifluoroaniline, Benzenamine, 2,3,4-trifluoro-, Aniline, 2,3,4-trifluoro-, BRN 3245609, Benzenamine, 2,3,4-trifluoro-C198, DTXSID60959469, EC 407-170-9, 4-12-00-01114 (Beilstein Handbook Reference), DTXCID001387346, 407-170-9, 627-409-2, wrdgnxcxtddybz-uhfffaoysa-n, 3862-73-5, 2,3,4-Trifluorobenzenamine, 2,3,4-trifluoraniline, 2,3,4-Trifluoro-phenylamine, 2,3,4-trifluorophenylamine, 2,3,4-trifluoro aniline, MFCD00011737, 2,3, 4-Trifluoroaniline, SCHEMBL112835, SCHEMBL2234071, SCHEMBL2965850, 2,3,4-Trifluoroaniline, 98%, STR04856, SBB012347, STL353604, AKOS000119730, CS-W010988, AC-10243, ST067118, DB-030756, A6528, A6771, NS00006091, T1385, EN300-19314, 2,3,4-Trifluorobenzenamine2,3,4-(Trifluoro)aniline, F2190-0496, Z104473516

Application

2,3,4-Trifluoroaniline is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS and antimicrobial therapies. Its electron-deficient aromatic ring facilitates efficient Suzuki-Miyaura and Buchwald-Hartwig couplings. In agrochemistry, it serves as a precursor for herbicides and fungicides with enhanced bioavailability. Researchers also employ it in material science to engineer liquid crystals and fluorinated polymers with unique thermal and optical properties.

Safety and Hazards

GHS Hazard Statements

• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H312: Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P391, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (100%)
• STOT RE 2 (50%)
• Aquatic Chronic 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.