Description

2,3-Difluoroanisole (CAS No. 134364-69-5) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₆F₂O. Also known as 1,2-difluoro-3-methoxybenzene, this specialty chemical is a valuable building block in organic synthesis, particularly for pharmaceuticals, agrochemicals, and advanced material applications. Its unique fluorine substitution pattern enhances reactivity and stability, making it ideal for nucleophilic aromatic substitution (S_NAr) reactions and cross-coupling methodologies. Available in >98% purity (GC), this compound is rigorously tested for consistency and packaged under inert conditions to ensure long-term stability. Suitable for research, process development, and scale-up, 2,3-Difluoroanisole is a critical reagent for medicinal chemists and material scientists.

Properties

• CAS Number: 134364-69-5
• Complexity: 108
• IUPAC Name: 1,2-difluoro-3-methoxy-benzene
• InChI: InChI=1S/C7H6F2O/c1-10-6-4-2-3-5(8)7(6)9/h2-4H,1H3
• InChI Key: RDOGTTNFVLSBKG-UHFFFAOYSA-N
• Exact Mass: 144.03867113
• Molecular Formula: C7H6F2O
• Molecular Weight: 144.12
• SMILES: COC1=C(C(=CC=C1)F)F
• Topological: 9.2
• Monoisotopic Mass: 144.03867113
• Synonyms: 2,3-Difluoroanisole, 134364-69-5, 1,2-difluoro-3-methoxybenzene, RDOGTTNFVLSBKG-UHFFFAOYSA-, DTXSID20377680, DTXCID70328708, 603-810-8, inchi=1/c7h6f2o/c1-10-6-4-2-3-5(8)7(6)9/h2-4h,1h3, 1,2-difluoro-3-methoxy-benzene, MFCD01631562, Benzene, 1,2-difluoro-3-methoxy-, 2,3-difluoro-1-methoxybenzene, 2,3-difluoroanisol, difluro-methoxybenzen, SCHEMBL196734, SCHEMBL533456, SCHEMBL1547396, SCHEMBL2288733, SCHEMBL2352053, SCHEMBL13322162, 2, 3-difluoro-4-methoxybenzene, SBB055052, AKOS005762906, AC-3782, CS-W002796, FD70438, PS-8978, SY014649, DB-023726, D3359, NS00124926, ST50823889, EN300-156690

Application

2,3-Difluoroanisole serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, including kinase inhibitors and CNS-active compounds. Its electron-deficient aromatic ring facilitates selective functionalization for agrochemical derivatives such as herbicides and fungicides. The compound is also employed in liquid crystal and polymer research, where fluorine incorporation modifies thermal and optical properties.

Safety and Hazards

GHS Hazard Statements

• H226 (14.3%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (85.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (85.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (14.3%)
• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (85.7%)
• Eye Irrit. 2A (85.7%)
• STOT SE 3 (85.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.