Description

2′,3′-Difluoroacetophenone (CAS No. 18355-80-1) is a high-purity fluorinated aromatic ketone with the molecular formula C₈H₆F₂O. This compound, also known by its IUPAC name 1-(2,3-difluorophenyl)ethanone, is a versatile building block in organic synthesis and pharmaceutical research. Its unique difluorinated structure enhances reactivity and stability, making it ideal for applications in medicinal chemistry, agrochemical development, and material science. Available in >98% purity (GC), this reagent is rigorously tested for consistency and performance. Suitable for use in nucleophilic substitutions, cross-coupling reactions, and as a precursor for heterocyclic compounds. Packaged under inert gas to ensure long-term stability and shipped with detailed analytical certificates (COA, MSDS).

Properties

• CAS Number: 18355-80-1
• Complexity: 158
• IUPAC Name: 1-(2,3-difluorophenyl)ethanone
• InChI: InChI=1S/C8H6F2O/c1-5(11)6-3-2-4-7(9)8(6)10/h2-4H,1H3
• InChI Key: PQUXFUBNSYCQAL-UHFFFAOYSA-N
• Exact Mass: 156.03867113
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.13
• SMILES: CC(=O)C1=C(C(=CC=C1)F)F
• Topological: 17.1
• Monoisotopic Mass: 156.03867113
• Synonyms: 18355-80-1, 2′,3′-Difluoroacetophenone, DTXSID10334065, DTXCID20285155, 639-314-3, 1-(2,3-Difluorophenyl)ethanone, 2,3-Difluoroacetophenone, Ethanone, 1-(2,3-difluorophenyl)-, 1-(2,3-difluorophenyl)ethan-1-one, 1-(2,3-difluoro-phenyl)-ethanone, MFCD00061274, 1-acetyl-2,3-difluorobenzene, SCHEMBL717464, SCHEMBL2090285, CHEMBL4578486, SCHEMBL17474445, SCHEMBL17474448, 1-(2,3-difluoro phenyl)ethanone, 1-(2,3-Difluorophenyl)ethanone #, SBB087125, AKOS009158129, FD38713, PS-8848, SB34598, DB-044497, ST50824554, EN300-124907

Application

2′,3′-Difluoroacetophenone is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals, including protease inhibitors and CNS-active compounds. Its electron-withdrawing fluorine atoms facilitate regioselective reactions in complex organic transformations. Researchers also employ it in the development of liquid crystals and advanced polymeric materials due to its aromatic stability and low polarizability.

Safety and Hazards

GHS Hazard Statements

• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (85.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (14.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (85.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (85.7%)
• Eye Dam. 1 (14.3%)
• Eye Irrit. 2 (85.7%)
• STOT SE 3 (85.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.