Description

2,3-Difluoro-N-hydroxy-6-(trifluoromethyl)benzimidamide (CAS No. 180410-47-3) is a high-purity fluorinated benzimidamide derivative designed for advanced research and pharmaceutical applications. With the molecular formula C₈H₅F₅N₂O, this compound features a unique trifluoromethyl group and hydroxylamine functionality, making it a versatile building block for medicinal chemistry and agrochemical synthesis. Its exceptional stability and reactivity under controlled conditions ensure reliable performance in cross-coupling reactions, nucleophilic substitutions, and other critical transformations. Ideal for researchers seeking to explore novel fluorinated scaffolds, this product is rigorously tested for purity (>98% by HPLC) and supplied with comprehensive analytical data (NMR, MS, IR). Store under inert conditions at -20°C to maintain optimal stability.

Properties

• CAS Number: 180410-47-3
• Complexity: 280
• IUPAC Name: 2,3-difluoro-N’-hydroxy-6-(trifluoromethyl)benzamidine
• InChI: InChI=1S/C8H5F5N2O/c9-4-2-1-3(8(11,12)13)5(6(4)10)7(14)15-16/h1-2,16H,(H2,14,15)
• InChI Key: VYYGIBIHKAKDQL-UHFFFAOYSA-N
• Exact Mass: 240.03220360
• Molecular Formula: C8H5F5N2O
• Molecular Weight: 240.13
• SMILES: C1=CC(=C(C(=C1C(F)(F)F)C(=NO)N)F)F
• Topological: 58.6
• Monoisotopic Mass: 240.03220360
• Synonyms: 2,3-Difluoro-N-hydroxy-6-(trifluoromethyl)benzimidamide, 180410-47-3, SCHEMBL7916930, 2,3 difluoro-6-trifluoromethylbenzamidoxime, 2,3-difluoro-6-trifluoromethylbenzamidoxime, DB-292158

This compound serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and antimicrobial agents. Its reactive amidoxime group enables facile derivatization into heterocyclic frameworks, such as oxadiazoles and triazoles. Researchers also utilize it in materials science for designing fluorine-rich polymers with enhanced thermal and chemical resistance. Suitable for high-throughput screening and structure-activity relationship (SAR) studies in drug discovery pipelines.

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