Description

2,3-Difluoro-6-nitrophenol (CAS No. 82419-26-9) is a high-purity fluorinated nitrophenol derivative with the molecular formula C₆H₃F₂NO₃. This compound is characterized by its distinct aromatic structure featuring two fluorine substituents at the 2- and 3-positions and a nitro group at the 6-position of the phenol ring. It is a valuable building block in synthetic organic chemistry, particularly for the development of pharmaceuticals, agrochemicals, and advanced materials. The presence of both electron-withdrawing fluorine and nitro groups enhances its reactivity in nucleophilic substitution and coupling reactions. Available in various quantities, this product is rigorously tested to ensure ≥95% purity (HPLC/GC) and is supplied with comprehensive analytical data, including ¹H NMR, ¹³C NMR, and MS spectra. Suitable for research and industrial applications, it is packaged under inert conditions to guarantee stability and longevity.

Properties

• CAS Number: 82419-26-9
• Complexity: 184
• IUPAC Name: 2,3-difluoro-6-nitro-phenol
• InChI: InChI=1S/C6H3F2NO3/c7-3-1-2-4(9(11)12)6(10)5(3)8/h1-2,10H
• InChI Key: KEGOHDCHURMFKX-UHFFFAOYSA-N
• Exact Mass: 175.00809928
• Molecular Formula: C6H3F2NO3
• Molecular Weight: 175.09
• SMILES: C1=CC(=C(C(=C1[N+](=O)[O-])O)F)F
• Topological: 66.1
• Monoisotopic Mass: 175.00809928
• Synonyms: 2,3-Difluoro-6-nitrophenol, 82419-26-9, DTXSID30369995, DTXCID10321031, 624-586-8, kegohdchurmfkx-uhfffaoysa-n, MFCD00042255, 2-hydroxy-3,4-difluoronitrobenzene, phenol, 2,3-difluoro-6-nitro-, 6-Nitro-2,3-difluorophenol, 2,3 difluoro 6-nitrophenol, 2-nitro-5,6-difluorophenol, SCHEMBL521166, 2,3 difluoro 6-nitro phenol, 2,3-difluoro-6- nitrophenol, 2-hydroxy-3,4 difluoronitrobenzene, 2,3-Difluoro-6-nitrophenol, 98%, SBB063663, AKOS005254310, CS-W001649, FD69832, AC-13837, BP-20251, DS-14700, SY022618, DB-008121, D2705, ST50826913, O10573

Application

2,3-Difluoro-6-nitrophenol serves as a versatile intermediate in the synthesis of fluorinated aromatic compounds, particularly in pharmaceutical and agrochemical research. Its electron-deficient aromatic ring makes it suitable for nucleophilic aromatic substitution reactions, enabling the creation of complex heterocycles. Researchers utilize this compound in the development of active pharmaceutical ingredients (APIs) and specialty chemicals requiring fluorophenol motifs. It is also employed in material science for designing advanced polymers and liquid crystals with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (89.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (91.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (89.1%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (91.3%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.