Description

2,3-Difluoro-4-methoxybenzeneboronic acid (CAS No. 170981-41-6) is a high-purity boronic acid derivative widely utilized in organic synthesis, pharmaceutical research, and material science. With the molecular formula C₇H₇BF₂O₃, this compound serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling the formation of complex biaryl structures critical in drug discovery and advanced material development. Its unique fluorine and methoxy substituents enhance reactivity and selectivity, making it ideal for precision chemical modifications.

This product is rigorously tested to ensure ≥95% purity (HPLC/GC), with trace moisture and residual solvent levels minimized for optimal performance. Available in sealed amber vials or bulk quantities, it is stored under inert conditions to preserve stability. Suitable for researchers requiring reliable, high-quality intermediates for catalysis, medicinal chemistry, and agrochemical applications.

Properties

• CAS Number: 170981-41-6
• Complexity: 170
• IUPAC Name: (2,3-difluoro-4-methoxy-phenyl)boronic acid
• InChI: InChI=1S/C7H7BF2O3/c1-13-5-3-2-4(8(11)12)6(9)7(5)10/h2-3,11-12H,1H3
• InChI Key: HIWYFMBSFSTYGU-UHFFFAOYSA-N
• Exact Mass: 188.0456306
• Molecular Formula: C7H7BF2O3
• Molecular Weight: 187.94
• SMILES: B(C1=C(C(=C(C=C1)OC)F)F)(O)O
• Topological: 49.7
• Monoisotopic Mass: 188.0456306
• Synonyms: 2,3-DIFLUORO-4-METHOXYBENZENEBORONIC ACID, 800-548-8, 170981-41-6, 2,3-DIFLUORO-4-METHOXYPHENYLBORONIC ACID, (2,3-difluoro-4-methoxyphenyl)boronic acid, MFCD07368234, Boronic acid, (2,3-difluoro-4-methoxyphenyl)-, 2,3-difluoro-4-methoxyphenylboronic aicd, (2,3-Difluoro-4-methoxyphenyl)boronicacid, (2,3-Difluoro-4-methoxy-phenyl)boronic acid, SCHEMBL1445093, DTXSID10648598, HIWYFMBSFSTYGU-UHFFFAOYSA-N, SBB071154, AKOS006223642, AB31961, CS-W016834, DS-14795, SY018050, DB-019732, D5016, N11962, EN300-3195049, A811278, [2,3-bis(fluoranyl)-4-methoxy-phenyl]boronic acid, Z1201624025, 2,3-Difluoro-4-methoxyphenylboronic Acid (contains varying amounts of Anhydride)

2,3-Difluoro-4-methoxybenzeneboronic acid is primarily employed in Suzuki-Miyaura cross-coupling reactions to synthesize fluorinated biaryl compounds for pharmaceutical candidates. Its electron-withdrawing fluorine atoms improve reaction efficiency in Pd-catalyzed transformations. Researchers also use it to develop liquid crystal materials and agrochemical intermediates. The methoxy group further enhances solubility in organic solvents, facilitating diverse synthetic workflows.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.