Description

2,3-Dichloro-4-iodopyridine (CAS No. 889865-45-6) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂Cl₂IN. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both chlorine and iodine substituents on the pyridine ring, enables selective functionalization for cross-coupling reactions (e.g., Suzuki, Stille, or Negishi couplings). Ideal for medicinal chemistry applications, it is supplied as a crystalline solid with ≥95% purity (HPLC) and rigorously tested for consistency. Packaged under inert gas to ensure stability, this product is designed for researchers requiring reliable intermediates for heterocyclic compound development.

Properties

• CAS Number: 889865-45-6
• Complexity: 101
• IUPAC Name: 2,3-dichloro-4-iodo-pyridine
• InChI: InChI=1S/C5H2Cl2IN/c6-4-3(8)1-2-9-5(4)7/h1-2H
• InChI Key: WRPBPDPXVUBWCR-UHFFFAOYSA-N
• Exact Mass: 272.86090
• Molecular Formula: C5H2Cl2IN
• Molecular Weight: 273.88
• SMILES: C1=CN=C(C(=C1I)Cl)Cl
• Topological: 12.9
• Monoisotopic Mass: 272.86090
• Synonyms: 2,3-Dichloro-4-iodopyridine, 889865-45-6, DTXSID70661263, DTXCID10612012, 662-872-4, 2,3-Dichloro-4-iodo-pyridine, MFCD11857737, Pyridine, 2,3-dichloro-4-iodo-, SCHEMBL564546, SCHEMBL29041596, WRPBPDPXVUBWCR-UHFFFAOYSA-N, 2,3-Dichloro-4-iodopyridine, 97%, AKOS005072340, CS-W007832, DD-0734, SB39642, AC-27997, SY040799, DB-083304, EN300-206159, 2,3-Dichloro-4-iodopyridine;Abbypharma ap-13-5524;

Application

2,3-Dichloro-4-iodopyridine serves as a key intermediate in the synthesis of bioactive molecules, including kinase inhibitors and antimicrobial agents. Its halogenated pyridine core facilitates site-selective modifications for drug discovery pipelines. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to construct complex heteroaromatic scaffolds. It is also employed in material science for developing functionalized ligands in catalysis.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (100%)
• Eye Irrit. 2A (100%)

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