Description

2,3-Dibromo-5-fluoropyridine (CAS No. 878207-82-0) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₂Br₂FN. This compound is an essential building block in pharmaceutical and agrochemical synthesis, offering versatile reactivity due to its dibromo and fluoro substituents. Its precise molecular weight (254.88 g/mol) and well-characterized structure make it ideal for cross-coupling reactions, nucleophilic substitutions, and other functionalization processes. Supplied as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested for consistency and stability. Suitable for use in medicinal chemistry, material science, and as a precursor for advanced heterocyclic compounds. Store under inert conditions at 2-8°C to maintain integrity.

Properties

• CAS Number: 878207-82-0
• Complexity: 101
• IUPAC Name: 2,3-dibromo-5-fluoro-pyridine
• InChI: InChI=1S/C5H2Br2FN/c6-4-1-3(8)2-9-5(4)7/h1-2H
• InChI Key: ASHZMYYXNMJUDZ-UHFFFAOYSA-N
• Exact Mass: 254.85175
• Molecular Formula: C5H2Br2FN
• Molecular Weight: 254.88
• SMILES: C1=C(C=NC(=C1Br)Br)F
• Topological: 12.9
• Monoisotopic Mass: 252.85380
• Synonyms: 2,3-dibromo-5-fluoropyridine, 878207-82-0, DTXSID50628596, DTXCID20579349, 813-497-1, 2,3-Dibromo-5-fluoro-pyridine, MFCD08532501, Pyridine, 2,3-dibromo-5-fluoro-, SCHEMBL845314, ASHZMYYXNMJUDZ-UHFFFAOYSA-N, BCP22118, SBB101511, AKOS015835781, PS-7422, SY029542, DB-081724, CS-0005594, EN300-119719

Application

2,3-Dibromo-5-fluoropyridine serves as a key intermediate in Suzuki-Miyaura and Stille cross-coupling reactions for constructing complex fluorinated heterocycles. It is widely employed in pharmaceutical research for developing kinase inhibitors and bioactive molecules targeting CNS disorders. The compound’s reactivity also enables its use in synthesizing fluorinated liquid crystals and electronic materials. Researchers leverage its halogenated pyridine core for late-stage functionalization in drug discovery pipelines.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (66.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (66.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (66.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (66.7%)
• STOT SE 3 (100%)

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