Description

2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctane (CAS No. 7381-30-8), also known as trimethyl(2-trimethylsilyloxyethoxy)silane, is a high-purity organosilicon compound with the molecular formula C₈H₂₂O₂Si₂. This colorless to pale yellow liquid is widely utilized in organic synthesis, surface modification, and as a protecting group reagent due to its excellent hydrolytic stability and reactivity. Its bifunctional structure, featuring two trimethylsilyl (TMS) groups linked by an ethylene glycol bridge, makes it a versatile intermediate for silylation reactions. Suitable for laboratory and industrial applications, this compound is packaged under inert gas to ensure stability and longevity. Store in a cool, dry place away from moisture and strong oxidizers.

Properties

• CAS Number: 7381-30-8
• Complexity: 108
• IUPAC Name: trimethyl(2-trimethylsilyloxyethoxy)silane
• InChI: InChI=1S/C8H22O2Si2/c1-11(2,3)9-7-8-10-12(4,5)6/h7-8H2,1-6H3
• InChI Key: JGWFUSVYECJQDT-UHFFFAOYSA-N
• Exact Mass: 206.11583301
• Molecular Formula: C8H22O2Si2
• Molecular Weight: 206.43
• SMILES: C[Si](C)(C)OCCO[Si](C)(C)C
• Topological: 18.5
• Monoisotopic Mass: 206.11583301
• Synonyms: 1,2-Bis(trimethylsiloxy)ethane, 2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctane, 3,6-Dioxa-2,7-disilaoctane, 2,2,7,7-tetramethyl-, EINECS 230-950-3, Ethylene glycol, di-TMS, DTXSID90224233, Ethylene glycol, 2TMS derivative, Ethylene glycol, bistrimethylsilyl ether, DTXCID90146724, 230-950-3, jgwfusvyecjqdt-uhfffaoysa-n, 7381-30-8, 1,2-Bis(trimethylsilyloxy)ethane, trimethyl(2-trimethylsilyloxyethoxy)silane, Ethylenedioxybis(trimethylsilane), Ethylene glycol bis(trimethylsilyl ether), MFCD00009640, 1,2-Bis-trimethylsilanyloxy-ethane, 1,?2-?Bis(trimethylsiloxy)?ethane, C8H22O2Si2, SCHEMBL1223591, 1,2-bis-(trimethylsilyloxy)ethane, 1,2-bis-(trimethylsilyloxy)-ethane, (CH3)3SiO(CH2)2OSi(CH3)3, AKOS015909268, 1,2-Bis(trimethylsiloxy)ethane, 98%, FS-4963, 1,2-BIS(TRIMETHYLSILYLOXY)-ETHANE, DB-002719, CS-0128798, E0478, NS00047076, S02325

Application

2,2,7,7-Tetramethyl-3,6-dioxa-2,7-disilaoctane is commonly employed as a protecting group for diols and hydroxyl-containing compounds in organic synthesis. It serves as a precursor for silicon-based coatings and surface modifiers, enhancing hydrophobicity and chemical resistance in materials science. Additionally, this compound is used in the preparation of specialty siloxane polymers and as a reagent in pharmaceutical intermediates.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)

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