Description

2,2,5,5-Tetramethyltetrahydrofuran (CAS No. 15045-43-9) is a high-purity, cyclic ether compound with the molecular formula C₈H₁₆O. Also known by its IUPAC name 2,2,5,5-tetramethyloxolane, this specialty chemical is characterized by its unique sterically hindered structure, featuring four methyl groups symmetrically positioned around the tetrahydrofuran ring. This configuration imparts exceptional stability and makes it valuable for advanced synthetic applications.

Our product is rigorously tested to meet the highest standards of purity, ensuring optimal performance in sensitive chemical processes. It is supplied in sealed containers under inert atmosphere to maintain integrity. Typical applications include use as a specialty solvent in organometallic chemistry, a building block in pharmaceutical synthesis, and a precursor for advanced material development.

Key specifications include:

• Molecular Weight: 128.21 g/mol
• Boiling Point: 116-118°C
• Density: 0.83 g/mL at 25°C
• Refractive Index: n_D²⁰ 1.412

Properties

• CAS Number: 15045-43-9
• Complexity: 99.7
• IUPAC Name: 2,2,5,5-tetramethyltetrahydrofuran
• InChI: InChI=1S/C8H16O/c1-7(2)5-6-8(3,4)9-7/h5-6H2,1-4H3
• InChI Key: BBLDTXFLAHKYFJ-UHFFFAOYSA-N
• Exact Mass: 128.120115130
• Molecular Formula: C8H16O
• Molecular Weight: 128.21
• SMILES: CC1(CCC(O1)(C)C)C
• Topological: 9.2
• Monoisotopic Mass: 128.120115130
• Physical Description: Colorless liquid;
• Vapor Pressure: 14.4 [mmHg]
• Synonyms: 2,2,5,5-TETRAMETHYLTETRAHYDROFURAN, Furan, tetrahydro-2,2,5,5-tetramethyl-, Tetrahydro-2,2,5,5-tetramethylfuran, EINECS 239-117-9, UNII-83Z08D4U0T, AI3-25141, 83Z08D4U0T, DTXSID1022263, DTXCID602263, Tetrahydro2,2,5,5tetramethylfuran, Furan, tetrahydro2,2,5,5tetramethyl, bbldtxflahkyfj-uhfffaoysa-n, un3271, 15045-43-9, 2,2,5,5-tetramethyloxolane, SCHEMBL380315, SCHEMBL10871250, CHEBI:210533, GEO-03959, MFCD00005368, AKOS015912795, 2,2,5,5-Tetramethyl-tetrahydro-furan, AS-63484, FT172401, DB-043055, NS00021680, D92900, EN300-7353614, Q25323734

Application

2,2,5,5-Tetramethyltetrahydrofuran serves as a valuable solvent for air-sensitive organometallic reactions due to its steric hindrance and oxygen stability. The compound finds application in asymmetric synthesis as a chiral auxiliary in pharmaceutical intermediates. Researchers utilize it as a precursor for developing specialty polymers with enhanced thermal stability. Its unique structure makes it suitable for studying steric effects in reaction mechanisms.

Safety and Hazards

GHS Hazard Statements

• H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H302 (91.3%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P317, P303+P361+P353, P330, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (100%)
• Acute Tox. 4 (91.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.