Description

2,2,3,3-Tetrafluoro-1-propanol (CAS 76-37-9) is a high-purity fluorinated alcohol with the molecular formula C₃H₄F₄O. This specialty chemical is characterized by its unique fluorinated structure, offering enhanced solubility, thermal stability, and chemical resistance compared to non-fluorinated alcohols. It is an essential reagent in organic synthesis, pharmaceutical intermediates, and advanced material applications. The compound is supplied as a clear, colorless liquid with a boiling point of approximately 109-110°C and a density of 1.42 g/cm³ at 25°C. Suitable for use in anhydrous reactions, it is stored under inert conditions to maintain stability. Ideal for researchers and industrial scientists requiring precise fluorination for tailored molecular designs.

Properties

• CAS Number: 76-37-9
• Complexity: 71.7
• IUPAC Name: 2,2,3,3-tetrafluoropropan-1-ol
• InChI: InChI=1S/C3H4F4O/c4-2(5)3(6,7)1-8/h2,8H,1H2
• InChI Key: NBUKAOOFKZFCGD-UHFFFAOYSA-N
• Exact Mass: 132.01982740
• Molecular Formula: C3H4F4O
• Molecular Weight: 132.06
• SMILES: C(C(C(F)F)(F)F)O
• Topological: 20.2
• Monoisotopic Mass: 132.01982740
• Synonyms: 2,2,3,3-Tetrafluoro-1-propanol, 76-37-9, 2,2,3,3-Tetrafluoropropan-1-ol, 2,2,3,3-TETRAFLUOROPROPANOL, 1H,1H,3H-Tetrafluoro-1-propanol, 1-Propanol, 2,2,3,3-tetrafluoro-, Tetrafluoropropyl alcohol, 2,2,3,3-Tetrafluoropropyl alcohol, C3-Fluoroalcohol, 1,1,3-Trihydroperfluoro-1-propanol, NSC 113, EINECS 200-955-5, UNII-RNO513716P, BRN 1738264, AI3-23784, NSC-113, RNO513716P, 1-Hydroxy-2,2,3,3-tetrafluoropropane, DTXSID8058796, 2,2,3,3-tetrafluoropropanol-1, 2,2,3,3-Tetrafluoro-propanol-1, 4-01-00-01438 (Beilstein Handbook Reference), 1,1,2,2-TETRAFLUORO-3-HYDROXYPROPANE, 2,2,3,3-TETRAFLUORO-1-PROPANOL [MI], .ALPHA.,.ALPHA.,.OMEGA.-TRIHYDROPERFLUOROPROPANOL, DTXCID0047828, ALPHA,ALPHA,OMEGA-TRIHYDROPERFLUOROPROPANOL, nbukaoofkzfcgd-uhfffaoysa-n, MFCD00004676, WLN: Q1XFFYFF, CHF2CF2CH2OH, HCF2CF2CH2OH, SCHEMBL22398, SCHEMBL22399, NSC113, SCHEMBL6593457, 2,3,3-Tetrafluoro-1-propanol, 2,3,3-Tetrafluoropropyl alcohol, 1,3-Trihydroperfluoro-1-propanol, 1-Propanol,2,3,3-tetrafluoro-, QGJNLZUASZXAGE-UHFFFAOYSA-N, BBL027472, STK802056, AKOS000120480, AT23334, CS-W013420, FT38883, BP-11316, 2,2,3,3-Tetrafluoro-1-propanol, 98%, DB-056051, NS00019240, T0101, EN300-20158, Q23978438, Z104477086

Application

2,2,3,3-Tetrafluoro-1-propanol is widely used as a solvent and intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its unique properties make it valuable in the development of specialty polymers and coatings with enhanced chemical resistance. Additionally, it serves as a key reagent in nucleophilic fluorination reactions and as a building block for advanced material science applications.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (53.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H319 (85.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (81.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (17.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P321, P330, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (53.9%)
• Eye Irrit. 2A (85.5%)
• Acute Tox. 3 (81.9%)
• Acute Tox. 4 (17.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.