Description

2,2,2,4′-Tetrafluoroacetophenone (CAS No. 655-32-3) is a high-purity fluorinated aromatic ketone with the molecular formula C₈H₄F₄O. This compound, also known by its IUPAC name 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring both trifluoromethyl and para-fluoro substituents, makes it an excellent intermediate for the development of fluorinated compounds with enhanced stability and bioavailability. Suitable for use in nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for agrochemicals and pharmaceuticals. Available in various quantities with ≥98% purity (GC), ensuring consistent performance in demanding applications.

Properties

• CAS Number: 655-32-3
• Complexity: 191
• IUPAC Name: 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone
• InChI: InChI=1S/C8H4F4O/c9-6-3-1-5(2-4-6)7(13)8(10,11)12/h1-4H
• InChI Key: LUKLMXJAEKXROG-UHFFFAOYSA-N
• Exact Mass: 192.01982740
• Molecular Formula: C8H4F4O
• Molecular Weight: 192.11
• SMILES: C1=CC(=CC=C1C(=O)C(F)(F)F)F
• Topological: 17.1
• Monoisotopic Mass: 192.01982740
• Synonyms: 2,2,2,4′-Tetrafluoroacetophenone, 655-32-3, 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone, p-Fluorotrifluoroacetophenone, 2,2,2-Trifluoro-1-(4-fluorophenyl)ethan-1-one, Ethanone, 2,2,2-trifluoro-1-(4-fluorophenyl)-, Acetophenone, 2,2,2,4′-tetrafluoro-, Y27QD2KWG8, p,alpha,alpha,alpha-Tetrafluoroacetophenone, 1-(4-fluorophenyl)-2,2,2-trifluoroethanone, EINECS 211-509-4, NSC 158171, NSC-158171, DTXSID3060958, 1-(4-Fluorophenyl)-2,2,2-trifluoroethan-1-one, DTXCID4044618, 211-509-4, MFCD00042393, 4′-Fluoro-2,2,2-trifluoroacetophenone, 4-Fluoro-A,A,A-trifluoroacetophenone, 4-fluoro-alpha,alpha,alpha-trifluoroacetophenone, NSC158171, alpha,alpha,alpha,4-Tetrafluoroacetophenone, UNII-Y27QD2KWG8, 2,2,2-trifluoro-1-(4-fluoro-phenyl)-ethanone, SCHEMBL16823, Acetophenone,2,2,4′-tetrafluoro-, 2,2,2,4′-Tetrafluoroacetophenone, CK2591, SBB091368, Acetophenone, 2,2,2,4′-tetrafluoro, AKOS009157031, 2,2,2,4a(2)-Tetrafluoroacetophenone, PS-8345, p,.alpha.,.alpha.-Tetrafluoroacetophenone, 2,2,2,4′-Tetrafluoroacetophenone, 99%, DB-054824, CS-0044502, NS00041833, ST51016153, T3257, Ethanone,2,2-trifluoro-1-(4-fluorophenyl)-, EN300-139244, Z1065649110, 2,2,2,4 inverted exclamation mark -Tetrafluoroacetophenone

Application

2,2,2,4′-Tetrafluoroacetophenone is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its electron-withdrawing properties make it valuable in the development of bioactive molecules with improved metabolic stability. Researchers also utilize this compound in materials science for creating fluorinated polymers and liquid crystals. Additionally, it serves as a precursor in the preparation of ligands for catalysis and specialty chemicals.

Safety and Hazards

GHS Hazard Statements

• H228 (100%): Flammable solid [Danger Flammable solids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P240, P241, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Sol. 1 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.