Description

2,2,2-Trifluoroethylhydrazine (CAS No. 5042-30-8) is a specialized organofluorine compound with the molecular formula C₂H₅F₃N₂. This high-purity reagent is widely utilized in synthetic organic chemistry, pharmaceutical research, and materials science due to its unique trifluoroethyl and hydrazine functional groups. The compound is supplied as a clear, colorless to pale yellow liquid with a characteristic amine-like odor, and is packaged under inert gas to ensure stability. With a molecular weight of 114.07 g/mol, it offers excellent reactivity in nucleophilic substitution reactions, cyclizations, and as a building block for heterocyclic compounds. Our product is rigorously tested for purity (typically ≥95% by GC) and is available in various quantities to suit laboratory-scale or process development needs. Proper storage at 2-8°C in a tightly sealed container is recommended to prevent degradation.

Properties

• CAS Number: 5042-30-8
• Complexity: 49.4
• IUPAC Name: 2,2,2-trifluoroethylhydrazine
• InChI: InChI=1S/C2H5F3N2/c3-2(4,5)1-7-6/h7H,1,6H2
• InChI Key: OPMFFAOEPFATTG-UHFFFAOYSA-N
• Exact Mass: 114.04048265
• Molecular Formula: C2H5F3N2
• Molecular Weight: 114.07
• SMILES: C(C(F)(F)F)NN
• Topological: 38.1
• Monoisotopic Mass: 114.04048265
• Synonyms: 2,2,2-trifluoroethylhydrazine, 225-734-0, 5042-30-8, (2,2,2-trifluoroethyl)hydrazine, 1-(2,2,2-trifluoroethyl)hydrazine, (2,2,2-Trifluoroethyl)hydrazine,65% in water, 2,2,2-Trifluoroethyl hydrazine, C2H5F3N2, EINECS 225-734-0, MFCD00007622, NSC111156, Hydrazine, (2,2,2-trifluoroethyl)-, 65% in water, trifluoroethyl hydrazine, CF3CH2NHNH2, SCHEMBL55461, 2,2,2-trifluorethylhydrazine, 1,1,1-trifluoroethylhydrazine, SCHEMBL2441172, SCHEMBL3749522, SCHEMBL3749525, 2,2,2-trifluoroethyl-hydrazine, 2,2,2-trifluoro-ethyl hydrazine, DTXSID10198462, OPMFFAOEPFATTG-UHFFFAOYSA-O, (2,2,2-trifluoro-ethyl)-hydrazine, STK352933, hydrazine, (2,2,2-trifluoro)ethyl-, AKOS000152096, NSC 111156, NSC-111156, AS-80882, DB-049780, CS-0158460, NS00045768, 2,2,2-Trifluoroethylhydrazine, 70% in water, EN300-139814, F20477, (2,2,2-Trifluoroethyl)hydrazine (70% in Water), 2,2,2-Trifluoroethylhydrazine (65-70% in water), 1-Hydrazino-2,2,2-trifluoroethane, 65 wt.% in H2O, 2,2,2-TRIFLUOROETHYLHYDRAZINE (65% WATER CONTENT)

Application

2,2,2-Trifluoroethylhydrazine serves as a versatile intermediate in the synthesis of fluorinated heterocycles and active pharmaceutical ingredients (APIs), particularly in the development of antiviral and anticancer agents. The compound’s reactive hydrazine moiety enables its use in the preparation of pyrazole, triazole, and other nitrogen-containing scaffolds with enhanced metabolic stability due to the trifluoroethyl group. Researchers employ this reagent in click chemistry applications and as a precursor for fluorinated agrochemicals. Its unique electronic properties also make it valuable in materials science for modifying surface characteristics of polymers.

Safety and Hazards

GHS Hazard Statements

• H228 (92.9%): Flammable solid [Danger Flammable solids]
• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (97.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (97.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P210, P240, P241, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, P370+P378, and P501

Hazard Classes and Categories

• Flam. Sol. 2 (92.9%)
• Acute Tox. 4 (97.6%)
• Acute Tox. 4 (97.6%)
• Acute Tox. 4 (97.6%)

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