Description

2,2,2-Trifluoroethylamine hydrochloride (CAS No. 373-88-6) is a high-purity organic compound with the molecular formula C₂H₅ClF₃N. This white to off-white crystalline powder is a valuable reagent in synthetic chemistry, particularly in the preparation of fluorinated pharmaceuticals, agrochemicals, and specialty materials. With its IUPAC name 2,2,2-trifluoroethanamine;hydrochloride, this compound offers excellent solubility in polar solvents like water, methanol, and ethanol, making it versatile for various reaction conditions. Each batch is rigorously tested for purity (typically ≥97-99%) via HPLC, GC, or NMR to ensure consistency for research and industrial applications. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability.

Properties

• CAS Number: 373-88-6
• Complexity: 38.5
• IUPAC Name: 2,2,2-trifluoroethanamine;hydrochloride
• InChI: InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H
• InChI Key: ZTUJDPKOHPKRMO-UHFFFAOYSA-N
• Exact Mass: 135.0062613
• Molecular Formula: C2H5ClF3N
• Molecular Weight: 135.51
• SMILES: C(C(F)(F)F)N.Cl
• Topological: 26
• Monoisotopic Mass: 135.0062613
• Synonyms: 2,2,2-Trifluoroethylamine hydrochloride, 373-88-6, Trifluoroethylamine hydrochloride, Ethanamine, 2,2,2-trifluoro-, hydrochloride, 2,2,2-Trifluoroethylamine, hydrochloride, EINECS 206-771-1, NSC 91733, ETHYLAMINE, TRIFLUORO-, HYDROCHLORIDE, Ethylamine, 2,2,2-trifluoro-, hydrochloride, Ethanamine, 2,2,2-trifluoro-, hydrochloride (1:1), DTXSID9059911, DTXCID9039311, Ethylamine, 2,2,2-trifluoro-, hydrochloride (8CI), 206-771-1, 2,2,2-trifluoroethanamine hydrochloride, 2,2,2-TRIFLUOROETHYLAMINE HCL, 2,2,2-trifluoroethan-1-amine hydrochloride, MFCD00012875, 2-Amino-1,1,1-trifluoroethane hydrochloride, NSC-91733, 2,2,2-Trifluoroethylaminehydrochloride, Trifluorethylamin HCl, C2H5ClF3N, WLN: Z1XFFF &GH, 7W3HH6ZDN9, SCHEMBL138414, 2,2,2-trifluoroethylamine-hcl, trifluoroethyl amine hydrochloride, BCP14597, NSC91733, FD2009, 2,2-Trifluoroethylamine hydrochloride, 2,2,2-trifluoroethanaminehydrochloride, AKOS005063337, 2,2-Trifluoroethylamine, hydrochloride, AC-6209, CS-W013336, PB47404, 2,2,2-triflouroethylamine hydrochloride, 2,2,2-trifluoroethanamine;hydrochloride, 2,2,2-trifluoroethylamine-hydrochloride, 2,2,2 trifluoroethyl amine hydrochloride, 2,2,2-trifluoro-ethanamine hydrochloride, 2,2,2-trifluoro-ethylamine hydrochloride, 2,2,2-Trifluoroethan-1-aminium chloride, AS-19363, Ethanamine,2,2-trifluoro-, hydrochloride, Ethylamine,2,2-trifluoro-, hydrochloride, SY017101, (2,2,2-trifluoroethyl)amine hydrochloride, 2, 2, 2-trifluoroethylamine hydrochloride, 2,2,2-trifluoroethylamine hydrogen chloride, DB-001191, 2,2,2-Trifluoro-1-ethanamine hydrochloride, Ethylamine, 2,2,2-trifluoro-,hydrochloride, NS00030186, T1170, 2,2,2-trifluoro-ethylamine hydrochloride salt, EN300-17178, 2,2,2-Trifluoroethylamine hydrochloride, 98%, F0001-1075, Z235149257

Application

2,2,2-Trifluoroethylamine hydrochloride serves as a key intermediate in the synthesis of fluorinated bioactive molecules, including antiviral and anticancer agents. It is widely used in peptide modification and as a building block for trifluoroethyl-containing compounds in medicinal chemistry. The compound’s trifluoroethyl group enhances metabolic stability and lipophilicity in drug candidates, making it valuable for pharmacokinetic optimization.

Safety and Hazards

GHS Hazard Statements

• H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (87.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (12.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (12.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (87.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (10.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (98%)
• Acute Tox. 4 (87.8%)
• Skin Irrit. 2 (12.2%)
• Eye Irrit. 2 (12.2%)
• Acute Tox. 4 (87.8%)
• STOT SE 3 (10.2%)

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