Description

2,2,2-Trifluoro-N,N-dimethylacetamide (CAS No. 1547-87-1) is a high-purity fluorinated organic compound with the molecular formula C₄H₆F₃NO. This versatile reagent is widely used in organic synthesis, pharmaceutical research, and material science due to its unique trifluoroacetyl group and dimethylamino functionality. Its exceptional solubility in polar organic solvents makes it an ideal candidate for peptide coupling reactions, amide bond formation, and as a precursor for advanced fluorinated materials. With a purity of ≥98%, this product is rigorously tested for quality assurance, ensuring consistent performance in sensitive applications. Packaged under inert gas to maintain stability, it is supplied in amber glass bottles to protect against light degradation. Researchers and scientists can rely on this compound for precise, reproducible results in demanding synthetic workflows.

Properties

• CAS Number: 1547-87-1
• Complexity: 117
• IUPAC Name: 2,2,2-trifluoro-N,N-dimethyl-acetamide
• InChI: InChI=1S/C4H6F3NO/c1-8(2)3(9)4(5,6)7/h1-2H3
• InChI Key: WXBWKMLIVXELSF-UHFFFAOYSA-N
• Exact Mass: 141.04014830
• Molecular Formula: C4H6F3NO
• Molecular Weight: 141.09
• SMILES: CN(C)C(=O)C(F)(F)F
• Topological: 20.3
• Monoisotopic Mass: 141.04014830
• Synonyms: 1547-87-1, 2,2,2-Trifluoro-N,N-dimethylacetamide, DTXSID70325570, DTXCID00276687, 671-651-1, N,N-Dimethyltrifluoroacetamide, Acetamide, 2,2,2-trifluoro-N,N-dimethyl-, MFCD00043555, NN-Dimethyltrifluoroacetamide, NSC511705, 2,2,2-trifluoro-nn-dimethylacetamide, Dimethyltrifluoroacetamide, Acetamide,2,2,2-trifluoro-N,N-dimethyl-, CF3CON(CH3)2, SCHEMBL321052, n,n-dimethyl-trifluoroacetamide, Trifluoro-N,N-dimethylacetamide, TZHNEAUIKHEGBD-UHFFFAOYSA-N, SBB008188, XH1032, AKOS000442190, NSC-511705, BS-31072, 2,2,2-Trifluoro-N,N-dimethylacetamide #, DB-043235, CS-0186467, T3262, D92685, EN300-1250797, Acetamide, 2,?2,?2-?trifluoro-?N,?N-?dimethyl-

2,2,2-Trifluoro-N,N-dimethylacetamide is primarily employed as a trifluoroacetylating agent in peptide synthesis and heterocyclic chemistry. It serves as a key intermediate in the production of pharmaceuticals, agrochemicals, and specialty fluoropolymers. The compound’s reactivity with nucleophiles enables its use in cross-coupling reactions and as a protecting group for amines. In material science, it contributes to the development of high-performance coatings and thermally stable polymers.

Safety and Hazards

GHS Hazard Statements

• H226 (66.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (33.3%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (33.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (66.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (66.7%)
• Acute Tox. 4 (33.3%)
• Acute Tox. 4 (33.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (33.3%)
• STOT SE 3 (66.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.