Description

2,2-Difluoropropylamine hydrochloride (CAS No. 868241-48-9) is a high-purity organic compound with the molecular formula C₃H₈ClF₂N. This white to off-white crystalline powder is a valuable building block in pharmaceutical and agrochemical research, offering exceptional reactivity due to its difluorinated amine structure. With a molecular weight of 127.55 g/mol, this hydrochloride salt exhibits excellent solubility in polar solvents like water, methanol, and DMSO, making it ideal for diverse synthetic applications. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed, light-resistant containers under inert atmosphere to guarantee stability. Suitable for use in nucleophilic substitution reactions, peptide coupling, and as a precursor for fluorinated heterocycles, this compound is a must-have for medicinal chemists exploring bioactive molecules with enhanced metabolic stability.

Properties

• CAS Number: 868241-48-9
• Complexity: 44.1
• IUPAC Name: 2,2-difluoropropan-1-amine;hydrochloride
• InChI: InChI=1S/C3H7F2N.ClH/c1-3(4,5)2-6;/h2,6H2,1H3;1H
• InChI Key: IDJKGOWDPKVIBR-UHFFFAOYSA-N
• Exact Mass: 131.0313333
• Molecular Formula: C3H8ClF2N
• Molecular Weight: 131.55
• SMILES: CC(CN)(F)F.Cl
• Topological: 26
• Monoisotopic Mass: 131.0313333
• Synonyms: 2,2-Difluoropropylamine hydrochloride, 868241-48-9, 639-411-0, 2,2-difluoropropan-1-amine Hydrochloride, 421-00-1, 2,2-difluoro-1-propylamine hydrochloride, 2,2-Difluoropropylamine HCl, 2,2-difluoropropan-1-amine;hydrochloride, MFCD06659051, C3H8ClF2N, 2,2-difluoropropylaminehydrochloride, 1-Propanamine, 2,2-difluoro-, hydrochloride, SCHEMBL1932230, DTXSID80962273, 2,2-difluoropropylamine, chloride, SBB085796, AKOS005063306, 2,2-difluoro-propylamine, hydrochloride, 2,2-difluoropropan-1-amineHydrochloride, DS-12434, SY029653, 1-Amino-2,2-difluoropropane hydrochloride, DB-005812, DB-121832, CS-0028374, 2,2-difluoropropan-1-amine hydrochloric acid, EN300-211424, 2 pound not2-Difluoropropan-1-amine hydrochloride, 2,2-Difluoropropan-1-amine–hydrogen chloride (1/1), F8881-8998, Z1201623622

Application

2,2-Difluoropropylamine hydrochloride serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly protease inhibitors and kinase modulators where the difluoromethyl group improves bioavailability. This compound is widely utilized in peptide chemistry for introducing fluorine-containing amino acid analogs that confer resistance to enzymatic degradation. Researchers also employ it in agrochemical development to create novel pesticides with increased environmental persistence. Its reactivity as a primary amine makes it valuable for constructing fluorinated heterocyclic scaffolds in drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.