Description

2,2-Difluoroethanamine (CAS No. 430-67-1) is a high-purity fluorinated amine compound with the molecular formula C₂H₅F₂N. This versatile building block is widely used in pharmaceutical, agrochemical, and materials science research due to its unique difluoroethylamine moiety. The compound is supplied as a clear, colorless to pale yellow liquid with a typical purity of ≥95% (GC). It is packaged under inert gas to ensure stability and shipped with detailed technical data including ¹H NMR, ¹³C NMR, and MS spectra for quality verification. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain optimal shelf life. This product is ideal for nucleophilic substitution reactions, heterocycle synthesis, and as a precursor for fluorinated bioactive molecules.

Properties

• CAS Number: 430-67-1
• Complexity: 21.6
• IUPAC Name: 2,2-difluoroethanamine
• InChI: InChI=1S/C2H5F2N/c3-2(4)1-5/h2H,1,5H2
• InChI Key: OVRWUZYZECPJOB-UHFFFAOYSA-N
• Exact Mass: 81.03900549
• Molecular Formula: C2H5F2N
• Molecular Weight: 81.06
• SMILES: C(C(F)F)N
• Topological: 26
• Monoisotopic Mass: 81.03900549
• Dissociation Constants: 7.3
• Synonyms: 2,2-difluoroethanamine, Ethanamine, 2,2-difluoro-, 671-709-6, 2,2-Difluoroethylamine, 430-67-1, 2,2-difluoroethan-1-amine, Ethylamine, 2,2-difluoro-, MFCD00798137, CF2HCH2NH2, difluoroethylamine, 2,2-difluorethylamine, 2,2,-difluorethylamine, 2,2-difluorethyl amine, LR6CDA8ZPD, 2,2-difluoro-ethanamine, 2,2-difluoro-ethylamine, 2,2-difluoroethyl amine, 2,2-difluoroethanaminium, 2,2-di-fluoro-ethylamine, 2,2-difluoro ethyl amine, EC 671-709-6, 2,2-difluoroethane-1-amine, SCHEMBL25759, 2,2-bis(fluoranyl)ethanamine, SCHEMBL379090, SCHEMBL403529, SCHEMBL1954609, CHEMBL1162281, DTXSID40195621, ethane, 1-amino-2,2-difluoro-, 2,2-Difluoroethylamine, AldrichCPR, BBL104334, SBB009831, STK350465, AKOS000312685, SY013766, DB-103869, D4758, NS00003724, ST45115291, EN300-115962, O10557, A826136

Application

2,2-Difluoroethanamine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of protease inhibitors and kinase modulators. In material science, it is employed to create fluorinated polymers with enhanced thermal and chemical resistance. The compound’s reactive amine group enables facile incorporation into complex molecular architectures for drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H290 (52.6%): May be corrosive to metals [Warning Corrosive to Metals]
• H302 (36.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (40.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (38.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (56.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (53.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P234, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P337+P317, P363, P390, P403+P233, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (52.6%)
• Acute Tox. 4 (36.8%)
• Skin Corr. 1B (40.8%)
• Eye Dam. 1 (38.2%)
• Eye Irrit. 2 (56.6%)
• STOT SE 3 (53.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.