Description

2,2-Difluoroethan-1-ol (CAS No. 359-13-7) is a high-purity fluorinated alcohol with the molecular formula C₂H₄F₂O, widely utilized in advanced chemical synthesis and material science applications. This compound, also known as 2,2-difluoroethanol, features a difluoromethyl group (-CF₂H) attached to a hydroxyl group (-OH), imparting unique reactivity and solvation properties. Its high polarity and hydrogen-bonding capacity make it an excellent solvent for specialized reactions, including nucleophilic substitutions and fluorination processes. With a purity grade of ≥98%, our product is rigorously tested via GC, NMR, and FTIR to ensure consistency for research and industrial use. Suitable for use as a building block in pharmaceuticals, agrochemicals, and fluoropolymer research, it is supplied in sealed amber glass bottles under inert gas to prevent degradation. Store in a cool, dry place away from oxidizing agents.

Properties

• CAS Number: 359-13-7
• Complexity: 21.6
• IUPAC Name: 2,2-difluoroethanol
• InChI: InChI=1S/C2H4F2O/c3-2(4)1-5/h2,5H,1H2
• InChI Key: VOGSDFLJZPNWHY-UHFFFAOYSA-N
• Exact Mass: 82.02302107
• Molecular Formula: C2H4F2O
• Molecular Weight: 82.05
• SMILES: C(C(F)F)O
• Topological: 20.2
• Monoisotopic Mass: 82.02302107
• Synonyms: 2,2-difluoroethan-1-ol, 670-547-3, 2,2-difluoroethanol, 359-13-7, Ethanol, 2,2-difluoro-, 2,2-Difluoro-ethanol, CHF2CH2OH, 2,2-difluroethanol, 2,2-Difluorethanol, MFCD00042248, 2,2-Difluoro ethanol, 2,2-difluoroethylalcohol, SCHEMBL4854, SCHEMBL23285, C2H4F2O, SCHEMBL938602, SCHEMBL2136306, SCHEMBL2927164, CHEMBL4458510, VOGSDFLJZPNWHY-UHFFFAOYSA-, DTXSID90189459, BCP05861, BBL038231, FD2062, SBB021966, STK263691, AKOS000310105, FD13236, DB-011467, A6246, CS-0020170, D4128, ST45128141, EN300-50881, InChI=1/C2H4F2O/c3-2(4)1-5/h2,5H,1H2, Z397587054

Application

2,2-Difluoroethan-1-ol serves as a versatile intermediate in organic synthesis, particularly in the preparation of fluorinated analogs of bioactive molecules. It is employed as a solvent in peptide coupling reactions and as a precursor for synthesizing fluorinated ethers and esters. Researchers also utilize it in material science to modify surface properties of polymers or as a co-solvent in electrolyte formulations for lithium-ion batteries.

Safety and Hazards

GHS Hazard Statements

• H225 (90%): Highly Flammable liquid and vapor [Danger Flammable liquids]
• H226 (10%): Flammable liquid and vapor [Warning Flammable liquids]
• H300 (20%): Fatal if swallowed [Danger Acute toxicity, oral]
• H301 (30%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302+H312+H332 (10%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (10%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (30%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H312 (10%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H330 (10%): Fatal if inhaled [Danger Acute toxicity, inhalation]
• H332 (10%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (90%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P284, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 2 (90%)
• Flam. Liq. 3 (10%)
• Acute Tox. 2 (20%)
• Acute Tox. 3 (30%)
• Acute Tox. 4 (10%)
• Acute Tox. 3 (30%)
• Acute Tox. 4 (10%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 2 (10%)
• Acute Tox. 4 (10%)
• STOT SE 3 (90%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.