Description

2,2-Difluoroacetamide (CAS No. 359-38-6) is a high-purity fluorinated organic compound with the molecular formula C₂H₃F₂NO. This white crystalline solid is a versatile building block in synthetic organic chemistry, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials. With its reactive amide group and two fluorine atoms, 2,2-difluoroacetamide serves as a valuable precursor for introducing difluoroacetyl motifs into target molecules. Our product is rigorously tested to ensure ≥98% purity (by GC or HPLC) and is supplied in sealed containers under inert atmosphere to maintain stability. Ideal for researchers working on fluorinated analogs of bioactive compounds or studying fluorine effects in medicinal chemistry.

Properties

• CAS Number: 359-38-6
• Complexity: 62.6
• IUPAC Name: 2,2-difluoroacetamide
• InChI: InChI=1S/C2H3F2NO/c3-1(4)2(5)6/h1H,(H2,5,6)
• InChI Key: ZMIBIIAWFMCVFD-UHFFFAOYSA-N
• Exact Mass: 95.01827004
• Molecular Formula: C2H3F2NO
• Molecular Weight: 95.05
• SMILES: C(C(=O)N)(F)F
• Topological: 43.1
• Monoisotopic Mass: 95.01827004
• Synonyms: 2,2-difluoroacetamide, 359-38-6, DTXSID40382034, DTXCID70333059, 818-090-2, Difluoroacetamide, Acetamide, 2,2-difluoro-, MFCD01896431, 2,2-Difluoro-acetamide, CHEMBL156852, C2H3F2NO, SCHEMBL692716, SCHEMBL917792, SCHEMBL1770470, SCHEMBL4744533, YMJDMVZTQVWJJQ-UHFFFAOYSA-N, ZMIBIIAWFMCVFD-UHFFFAOYSA-N, BDBM50226188, XH1340, AKOS003269748, SB85512, SY162673, CS-0109914, D76959, EN300-181159, Z33546481

Application

2,2-Difluoroacetamide is primarily used as a synthetic intermediate in pharmaceutical research, particularly for creating fluorinated analogs of drug candidates to enhance metabolic stability and bioavailability. In agrochemical development, it serves as a precursor for novel pesticides and herbicides with improved environmental persistence. The compound’s unique fluorine substitution pattern also makes it valuable in materials science for designing specialty polymers with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.