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Atomfair 2,2-Difluoro-1,3-benzodioxole C7H4F2O2 CAS 216-431-4

2,2-Difluoro-1,3-benzodioxole (CAS No. 216-431-4) is a high-purity fluorinated organic compound with the molecular formula C7H4F2O2. This specialty chemical is characterized by its unique benzodioxole core structure with two fluorine atoms at the 2-position, making it a valuable intermediate for pharmaceutical, agrochemical, and materials science research. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for use in nucleophilic substitution reactions, catalytic processes, and as a building block for advanced fluorinated materials. Available in quantities from 1g to 1kg with customizable packaging options. CAS: 216-431-4 / 1583-59-1 Molecular Weight:…

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Description

2,2-Difluoro-1,3-benzodioxole (CAS No. 216-431-4) is a high-purity fluorinated organic compound with the molecular formula C7H4F2O2. This specialty chemical is characterized by its unique benzodioxole core structure with two fluorine atoms at the 2-position, making it a valuable intermediate for pharmaceutical, agrochemical, and materials science research. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for use in nucleophilic substitution reactions, catalytic processes, and as a building block for advanced fluorinated materials. Available in quantities from 1g to 1kg with customizable packaging options.

  • CAS: 216-431-4 / 1583-59-1
  • Molecular Weight: 158.10 g/mol
  • Appearance: Colorless to pale yellow liquid
  • Storage: 2-8°C under inert atmosphere
  • Hazard Codes: Xi (Irritant)

Properties

  • CAS Number: 216-431-4
  • Complexity: 145
  • IUPAC Name: 2,2-difluoro-1,3-benzodioxole
  • InChI: InChI=1S/C7H4F2O2/c8-7(9)10-5-3-1-2-4-6(5)11-7/h1-4H
  • InChI Key: DGCOGZQDAXUUBY-UHFFFAOYSA-N
  • Exact Mass: 158.01793569
  • Molecular Formula: C7H4F2O2
  • Molecular Weight: 158.10
  • SMILES: C1=CC=C2C(=C1)OC(O2)(F)F
  • Topological: 18.5
  • Monoisotopic Mass: 158.01793569
  • Synonyms: 2,2-Difluoro-1,3-benzodioxole, 1583-59-1, EINECS 216-431-4, DTXSID60166398, EC 216-431-4, DTXCID5088889, 216-431-4, 2,2-difluorobenzo[d][1,3]dioxole, 2,2-Difluorobenzodioxole, 1,3-Benzodioxole, 2,2-difluoro-, 2,2-difluoro-2H-1,3-benzodioxole, 2,2-difluoro-benzodioxole, MFCD00236217, 1,2-(Difluoromethylenedioxy)benzene, 1,2-[(Difluoromethylene)dioxy]benzene; 2,2-Difluoro-1,3-benzodioxole; 2,2-Difluorobenzodioxole, SCHEMBL12038, SCHEMBL20278, SCHEMBL200514, 2,2-difluoro-1,3-dioxaindane, ROADUQBQMYHXFB-UHFFFAOYSA-N, 2,2-difluorobenzo[d]1,3-dioxolane, 2,2-difluorobenzo[d]1,3-dioxolene, SBB058476, AKOS000120916, CS-W002572, PS-6778, SB13158, 2,2-Difluoro-1,3-benzodioxole, 97%, DB-010878, D4051, NS00047286, ST50824665, EN300-20341

Application

2,2-Difluoro-1,3-benzodioxole serves as a key fluorinated synthon in medicinal chemistry for the development of bioactive molecules with enhanced metabolic stability. Its benzodioxole scaffold is utilized in materials science to create fluorinated polymers with improved thermal and chemical resistance. The compound’s reactivity also makes it valuable for synthesizing liquid crystal materials and specialty coatings where fluorine incorporation is critical for performance.

Safety and Hazards

GHS Hazard Statements

  • H226 (67.2%): Flammable liquid and vapor [Warning Flammable liquids]
  • H315 (99.1%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H317 (34.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
  • H319 (41.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (41.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P272, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 3 (67.2%)
  • Skin Irrit. 2 (99.1%)
  • Skin Sens. 1 (34.5%)
  • Eye Irrit. 2A (41.4%)
  • STOT SE 3 (41.4%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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