Description

2,2-Difluoro-1,3-benzodioxole (CAS No. 1583-59-1) is a high-purity fluorinated heterocyclic compound with the molecular formula C₇H₄F₂O₂. This specialty chemical features a benzodioxole core with two fluorine atoms at the 2-position, enhancing its reactivity and utility in synthetic applications. It is widely employed as a key intermediate in pharmaceuticals, agrochemicals, and advanced material synthesis. The compound is supplied as a clear to pale-yellow liquid with a purity of ≥97%, ensuring consistency for research and industrial use. Its stability under inert conditions and compatibility with various organic solvents make it a versatile reagent for scientists and engineers.

Available in secure, laboratory-grade packaging, our 2,2-Difluoro-1,3-benzodioxole meets stringent quality control standards, including GC/MS and NMR verification. Ideal for nucleophilic substitution reactions, cross-coupling protocols, and fluorination studies, this compound is a must-have for researchers exploring novel fluorine-containing architectures.

Properties

• CAS Number: 1583-59-1
• Complexity: 145
• IUPAC Name: 2,2-difluoro-1,3-benzodioxole
• InChI: InChI=1S/C7H4F2O2/c8-7(9)10-5-3-1-2-4-6(5)11-7/h1-4H
• InChI Key: DGCOGZQDAXUUBY-UHFFFAOYSA-N
• Exact Mass: 158.01793569
• Molecular Formula: C7H4F2O2
• Molecular Weight: 158.10
• SMILES: C1=CC=C2C(=C1)OC(O2)(F)F
• Topological: 18.5
• Monoisotopic Mass: 158.01793569
• Synonyms: 2,2-Difluoro-1,3-benzodioxole, 1583-59-1, EINECS 216-431-4, DTXSID60166398, EC 216-431-4, DTXCID5088889, 216-431-4, 2,2-difluorobenzo[d][1,3]dioxole, 2,2-Difluorobenzodioxole, 1,3-Benzodioxole, 2,2-difluoro-, 2,2-difluoro-2H-1,3-benzodioxole, 2,2-difluoro-benzodioxole, MFCD00236217, 1,2-(Difluoromethylenedioxy)benzene, 1,2-[(Difluoromethylene)dioxy]benzene; 2,2-Difluoro-1,3-benzodioxole; 2,2-Difluorobenzodioxole, SCHEMBL12038, SCHEMBL20278, SCHEMBL200514, 2,2-difluoro-1,3-dioxaindane, ROADUQBQMYHXFB-UHFFFAOYSA-N, 2,2-difluorobenzo[d]1,3-dioxolane, 2,2-difluorobenzo[d]1,3-dioxolene, SBB058476, AKOS000120916, CS-W002572, PS-6778, SB13158, 2,2-Difluoro-1,3-benzodioxole, 97%, DB-010878, D4051, NS00047286, ST50824665, EN300-20341

2,2-Difluoro-1,3-benzodioxole serves as a critical building block in the synthesis of fluorinated pharmaceuticals, particularly in the development of protease inhibitors and CNS-active compounds. It is also utilized in agrochemical research to create advanced pesticides with improved environmental stability. Additionally, this compound finds use in material science for designing fluorinated polymers with enhanced thermal and chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H226 (67.2%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (99.1%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (34.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (41.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (41.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P272, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (67.2%)
• Skin Irrit. 2 (99.1%)
• Skin Sens. 1 (34.5%)
• Eye Irrit. 2A (41.4%)
• STOT SE 3 (41.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.