Description

2,2-Diethoxyethylamine (CAS No. 645-36-3) is a highly versatile organic compound with the molecular formula C₆H₁₅NO₂. This clear to slightly yellow liquid is widely used in organic synthesis, pharmaceutical research, and specialty chemical applications. Its IUPAC name, 2,2-diethoxyethanamine, reflects its acetal-protected aminoaldehyde structure, making it a valuable building block for nucleophilic reactions and heterocyclic chemistry.

With a purity of ≥98%, our 2,2-Diethoxyethylamine is rigorously tested by GC and NMR to ensure consistency for sensitive applications. The compound is packaged under inert gas to maintain stability and shipped with detailed technical data, including MSDS and analytical certificates. Its balanced lipophilicity and reactivity make it ideal for constructing complex molecular architectures in medicinal chemistry and material science.

Key specifications include: Molecular Weight: 133.19 g/mol, Boiling Point: 180-182°C, Density: 0.916 g/mL at 25°C. Available in quantities from 100mL to 25L with customizable packaging options for industrial and research needs.

Properties

• CAS Number: 645-36-3
• Complexity: 53
• IUPAC Name: 2,2-diethoxyethanamine
• InChI: InChI=1S/C6H15NO2/c1-3-8-6(5-7)9-4-2/h6H,3-5,7H2,1-2H3
• InChI Key: HJKLEAOXCZIMPI-UHFFFAOYSA-N
• Exact Mass: 133.110278721
• Molecular Formula: C6H15NO2
• Molecular Weight: 133.19
• SMILES: CCOC(CN)OCC
• Topological: 44.5
• Monoisotopic Mass: 133.110278721
• Synonyms: 2,2-Diethoxyethylamine, Aminoacetaldehyde diethyl acetal, 2,2-Diethoxyethanamine, Ethanamine, 2,2-diethoxy-, diethoxyethylamine, Aminoacetaldehyde acetal, 1-amino-2,2-diethoxyethane, 658AO12BQL, EINECS 211-439-4, NSC-19501, UNII-658AO12BQL, 1,1-diethoxy-2-aminoethane, 2,2-bis(ethyloxy)ethanamine, DTXSID4060945, HJKLEAOXCZIMPI-UHFFFAOYSA-, DTXCID4044329, hjkleaoxczimpi-uhfffaoysa-n, inchi=1/c6h15no2/c1-3-8-6(5-7)9-4-2/h6h,3-5,7h2,1-2h3, 645-36-3, 2,2-diethoxyethan-1-amine, 2-Aminoacetaldehyde diethyl acetal, Glycinaldehyde diethyl acetal, Acetaldehyde, amino-, diethyl acetal, Aminoacetal, MFCD00008136, 2,2-diethoxy-ethylamine, NSC 19501, .alpha.-Aminoacetaldehyde diethyl acetal, .beta.,.beta.-Diethoxyethylamine, Aminoacetaldehydediethylacetal, Ethanamine,2-diethoxy-, 2,2-diethyoxyethylamine, 2,2-Diethoxy-ethanamin, 2,2-diethoxy ethanamine, 2,2-diethoxy-ethanamine, 2,2-diethoxyethyl amine, 2,2-diethoxy-ethyl-amine, aminoacetaldehyde diethylacetal, aminoacetaldehyde-diethylacetal, SCHEMBL289118, SCHEMBL730729, aminoacetoaldehyde diethylacetal, aminoacetaldehyde-diethyl acetal, SCHEMBL4732170, [2,2-bis(ethyloxy)ethyl]amine, aminoacetoaldehyde diethyl acetal, amino acetaldehyde diethyl acetal, amino-acetaldehyde diethyl acetal, CHEMBL5081110, 2-amino acetaldehyde diethylacetal, NSC19501, SBB004213, AKOS009031594, Aminoacetaldehyde diethyl acetal, 98%, .beta.-Aminoacetaldehyde diethyl acetal, CS-W001150, SB75608, AS-13474, FD177156, A0247, A8830, NS00035713, EN300-20378, F11269, F2190-0378, Z104477928

Application

2,2-Diethoxyethylamine serves as a protected aminoaldehyde equivalent in pharmaceutical syntheses, particularly for creating β-amino alcohols and heterocycles. It’s employed as a key intermediate in the production of vasodilators and CNS-active compounds. The diethoxy group provides stability while allowing controlled deprotection for selective reactions. Researchers utilize it in Schiff base formations and reductive aminations where controlled reactivity is required.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (26.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (73.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (17%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (73.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (73.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Corr. 1B (26.4%)
• Skin Irrit. 2 (73.6%)
• Eye Dam. 1 (17%)
• Eye Irrit. 2A (73.6%)
• STOT SE 3 (73.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.