Description

2-(Trifluoromethyl)aniline (CAS No. 88-17-5) is a high-purity aromatic amine derivative with the molecular formula C₇H₆F₃N. This compound features a trifluoromethyl group ortho to the amino functionality, making it a valuable building block in organic synthesis and pharmaceutical research. Its IUPAC name is 2-(trifluoromethyl)aniline, and it is also known by synonyms such as 2-Aminobenzotrifluoride and o-(Trifluoromethyl)aniline.

This product is supplied as a clear to pale yellow liquid with a characteristic amine odor. It is highly reactive and finds utility in nucleophilic substitution reactions, coupling reactions, and as a precursor for agrochemicals and drug intermediates. The trifluoromethyl group enhances the compound’s lipophilicity and metabolic stability, making it particularly useful in medicinal chemistry.

Our 2-(Trifluoromethyl)aniline is rigorously tested for purity and consistency, ensuring optimal performance in research and industrial applications. Proper storage in a cool, dry place under inert atmosphere is recommended to maintain its stability.

Properties

• CAS Number: 88-17-5
• Complexity: 132
• IUPAC Name: 2-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H6F3N/c8-7(9,10)5-3-1-2-4-6(5)11/h1-4H,11H2
• InChI Key: VBLXCTYLWZJBKA-UHFFFAOYSA-N
• Exact Mass: 161.04523368
• Molecular Formula: C7H6F3N
• Molecular Weight: 161.12
• SMILES: C1=CC=C(C(=C1)C(F)(F)F)N
• Topological: 26
• Monoisotopic Mass: 161.04523368
• Physical Description: 2-trifluoromethylaniline appears as a colorless liquid with a fishlike odor. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
• Synonyms: 2-(TRIFLUOROMETHYL)ANILINE, 2-Aminobenzotrifluoride, 88-17-5, 2-Trifluoromethylaniline, o-(Trifluoromethyl)aniline, Benzenamine, 2-(trifluoromethyl)-, alpha,alpha,alpha-Trifluoro-o-toluidine, CCRIS 2811, 2-trifluoromethylphenylamine, EINECS 201-806-7, 2-Trifluromethylaniline, AI3-26182, I1R59842CE, NSC-10336, UNII-I1R59842CE, DTXSID7058961, .alpha.,.alpha.,.alpha.-Trifluoro-o-toluidine, EC 201-806-7, UN 2942, 2-AMINO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTOLUENE, DTXCID3048609, 2-amino-alpha,alpha,alpha-trifluorotoluene, inchi=1/c7h6f3n/c8-7(9,10)5-3-1-2-4-6(5)11/h1-4h,11h, vblxctylwzjbka-uhfffaoysa-n, o-Aminobenzotrifluoride, o-Trifluoromethylaniline, 2-(Trifluoromethyl)benzenamine, 2-Trifluoromethyl-phenylamine, MFCD00007718, NSC 10336, o-(Trifluoromethyl)phenylamine, o-Toluidine, .alpha.,.alpha.,.alpha.-trifluoro-, 2-(trifluoromethyl)phenylamine, a,a,a-Trifluoro-O-toluidine, UN2942, 2-(trifluoromethyl) aniline, 2-trifluoromethylanilin, o-Toluidine, alpha,alpha,alpha-trifluoro-, o-trifluoromethyl aniline, 2-trifluoromethyl aniline, 2-trifluoromethyl-aniline, ortho trifluoromethylaniline, 2-(trifluoromethyl)-aniline, 2-trifluoromethyl phenylamine, SCHEMBL70554, BIDD:GT0808, SCHEMBL294231, CHEMBL249549, SCHEMBL2331156, SCHEMBL5314612, SCHEMBL6220544, 2-(trifluoromethyl)-Benzenamine, SCHEMBL11227825, [2-(trifluoromethyl)phenyl]amine, JFXRFURVRWWSPY-UHFFFAOYSA-N, 2-(Trifluoromethyl)aniline, 99%, NSC10336, SBB003955, STL163342, AKOS000119176, .alpha.,.alpha.-Trifluoro-o-toluidine, AT20036, CS-W004108, PS-8764, AC-10748, DB-346360, A0433, A7166, NS00004341, ST45255289, EN300-19102, 2-Aminotrifluorotoluene 2-Trifluoromethylaniline, 2-Trifluoromethylaniline [UN2942] [Poison], Q27280261, F2190-0434, Z104472784

Application

2-(Trifluoromethyl)aniline is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its trifluoromethyl group is often incorporated into bioactive molecules to enhance their lipophilicity and metabolic resistance. In medicinal chemistry, it serves as a precursor for the development of antifungal, antiviral, and anti-inflammatory agents. Additionally, this compound is employed in the production of dyes and pigments due to its aromatic amine functionality. Researchers also utilize it in cross-coupling reactions to create complex organic frameworks for material science applications.

Safety and Hazards

GHS Hazard Statements

• H226 (64%): Flammable liquid and vapor [Warning Flammable liquids]
• H301 (17.8%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302+H332 (15.7%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]
• H302 (80.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (17.8%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (80.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (60.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (78.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (18.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H332 (17.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H373 (80.1%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H411 (64.4%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
• H412 (15.7%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (64%)
• Acute Tox. 3 (17.8%)
• Acute Tox. 4 (80.9%)
• Acute Tox. 3 (17.8%)
• Skin Irrit. 2 (80.9%)
• Skin Sens. 1 (60.6%)
• Eye Irrit. 2 (78.8%)
• Acute Tox. 3 (18.2%)
• Acute Tox. 4 (17.4%)
• STOT RE 2 (80.1%)
• Aquatic Chronic 2 (64.4%)
• Aquatic Chronic 3 (15.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.