Description

2-(Trifluoromethyl)acrylic acid (CAS No. 381-98-6) is a high-purity fluorinated acrylic acid derivative with the molecular formula C₄H₃F₃O₂. This compound, also known by its IUPAC name 2-(trifluoromethyl)prop-2-enoic acid, is a versatile building block in organic synthesis and material science. Its unique trifluoromethyl group confers enhanced chemical stability, reactivity, and lipophilicity, making it valuable for pharmaceutical, agrochemical, and specialty polymer applications. Available in >98% purity (GC), this liquid reagent is packaged under inert gas to ensure stability and is ideal for nucleophilic addition, polymerization, and cross-coupling reactions. Compatible with anhydrous conditions and sensitive to moisture, it is supplied in amber glass bottles with secure closures to maintain integrity.

Properties

• CAS Number: 381-98-6
• Complexity: 146
• IUPAC Name: 2-(trifluoromethyl)prop-2-enoic acid
• InChI: InChI=1S/C4H3F3O2/c1-2(3(8)9)4(5,6)7/h1H2,(H,8,9)
• InChI Key: VLSRKCIBHNJFHA-UHFFFAOYSA-N
• Exact Mass: 140.00851382
• Molecular Formula: C4H3F3O2
• Molecular Weight: 140.06
• SMILES: C=C(C(=O)O)C(F)(F)F
• Topological: 37.3
• Monoisotopic Mass: 140.00851382
• Synonyms: 2-(Trifluoromethyl)acrylic acid, 381-98-6, TFMAA, DTXSID70343138, DTXCID30294218, 627-408-7, 2-(Trifluoromethyl)propenoic acid, 2-(trifluoromethyl)prop-2-enoic acid, MFCD00042424, trifluoromethacrylic acid, trifluoromethylacrylic acid, 2-Propenoic acid, 2-(trifluoromethyl)-, 2-trifluoromethylacrylic acid, a-trifluoromethylacrylic acid, SCHEMBL203037, SCHEMBL864818, 2-trifluoromethyl-acrylic acid, 2-trifluoromethylpropenoic acid, alpha-trifluoromethylacrylic acid, 2-(Trifluoromethyl)propenoicacid, VLSRKCIBHNJFHA-UHFFFAOYSA-, 2-(trifluoromethyl)-acrylic acid, LCQKGHGZNHWTIS-UHFFFAOYSA-N, 2-(Trifluoromethyl)acrylic acid #, BBL104085, SBB065852, STL557900, AKOS005063395, 2-(Trifluoromethyl)acrylic acid, 98%, AB01915, CS-W008276, AS-12599, SY021248, DB-019557, ST50823654, T1512, EN300-55260, F8880-0073, Z826034004, InChI=1/C4H3F3O2/c1-2(3(8)9)4(5,6)7/h1H2,(H,8,9)

Application

2-(Trifluoromethyl)acrylic acid is widely used as a monomer for synthesizing fluorinated polymers with improved chemical resistance and low surface energy. In pharmaceuticals, it serves as a key intermediate for introducing trifluoromethyl groups into bioactive molecules, enhancing metabolic stability. The compound is also employed in coatings and adhesives to modify material properties such as hydrophobicity and UV resistance.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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