Description

2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) is a high-purity boronic acid derivative with the molecular formula C₇H₆BF₃O₃ and CAS number 175676-65-0. This compound is a valuable building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its reactive boronic acid functional group. The trifluoromethoxy (-OCF₃) substituent enhances its utility in pharmaceutical and agrochemical research by imparting unique electronic and steric properties. Our product is rigorously tested for quality, ensuring optimal performance in demanding applications. Available in varying purities, it may contain trace amounts of anhydride, as noted in the product specifications.

Properties

• CAS Number: 175676-65-0
• Complexity: 186
• IUPAC Name: [2-(trifluoromethoxy)phenyl]boronic acid
• InChI: InChI=1S/C7H6BF3O3/c9-7(10,11)14-6-4-2-1-3-5(6)8(12)13/h1-4,12-13H
• InChI Key: AIJCNTOYZPKURP-UHFFFAOYSA-N
• Exact Mass: 206.0362087
• Molecular Formula: C7H6BF3O3
• Molecular Weight: 205.93
• SMILES: B(C1=CC=CC=C1OC(F)(F)F)(O)O
• Topological: 49.7
• Monoisotopic Mass: 206.0362087
• Synonyms: 2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride), 642-456-9, 175676-65-0, 2-(Trifluoromethoxy)phenylboronic acid, 2-Trifluoromethoxyphenylboronic acid, 2-(Trifluoromethoxy)benzeneboronic Acid, 2-(Trifluormethoxy)phenylboronic acid, [2-(trifluoromethoxy)phenyl]boronic Acid, (2-(trifluoromethoxy)phenyl)boronic acid, MFCD01320763, Boronic acid, B-[2-(trifluoromethoxy)phenyl]-, Boronic acid, [2-(trifluoromethoxy)phenyl]-, 2-Trifluormethoxyphenylboronic acid, SCHEMBL264406, DTXSID60380411, 2-Trifluoromethoxyphenylboronicacid, 2-Trifluoromethoxvphenylboronic acid, 2-trifluromethoxyphenyl boronic acid, 2-trifluoromethoxybenzeneboronic acid, 2-trifluoromethoxyphenyl boronic acid, BBL100497, SBB093560, STL554291, 2-(Trifluoromethoxy)benylboronic acid, 2-trifluoromethoxy-phenyl-boronic acid, AKOS004119240, 2-trifluoromethoxy benzene boronic acid, AB09004, AC-6987, CS-W020020, FT37712, 2-(Trifluoromethoxy)-phenylboronic acid, 2-(trifluoromethoxy)phenyl boronic acid, 2-(trifluoromethoxy)phenyl-boronic acid, (2-trifluoromethoxy-phenyl)-boronic acid, AS-12130, BP-10157, SY013469, DB-025025, T2413, EN300-49258, Z330829074, 2-(Trifluoromethoxy)phenylboronic acid (contains varying amounts of Anhydride)

Application

2-(Trifluoromethoxy)phenylboronic Acid is widely used in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, to synthesize biaryl compounds for pharmaceuticals and materials science. Its trifluoromethoxy group makes it a key intermediate in the development of CF₃-containing bioactive molecules, including potential drug candidates. Researchers also employ it in the synthesis of advanced ligands and catalysts for asymmetric transformations.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (88.9%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.