Description

2-(Trifluoromethoxy)phenol (CAS No. 32858-93-8) is a high-purity fluorinated phenolic compound with the molecular formula C₇H₅F₃O₂. This specialty chemical is widely utilized in pharmaceutical, agrochemical, and material science research due to its unique trifluoromethoxy functional group, which enhances reactivity and stability. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for demanding synthetic applications. Supplied in sealed glass vials under inert gas to maintain integrity, it is compatible with organic solvents and stable under standard laboratory conditions. Available in quantities ranging from 1g to 1kg, with custom packaging options upon request.

Properties

• CAS Number: 32858-93-8
• Complexity: 146
• IUPAC Name: 2-(trifluoromethoxy)phenol
• InChI: InChI=1S/C7H5F3O2/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4,11H
• InChI Key: GQWMNVOVQZIPJC-UHFFFAOYSA-N
• Exact Mass: 178.02416388
• Molecular Formula: C7H5F3O2
• Molecular Weight: 178.11
• SMILES: C1=CC=C(C(=C1)O)OC(F)(F)F
• Topological: 29.5
• Monoisotopic Mass: 178.02416388
• Synonyms: 2-(Trifluoromethoxy)phenol, 32858-93-8, GQWMNVOVQZIPJC-UHFFFAOYSA-, DTXSID70380462, DTXCID60331488, 642-553-6, inchi=1/c7h5f3o2/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4,11h, 2-(Trifluorormethoxy)phenol, 2-trifluoromethoxyphenol, 2-Hydroxyphenyl Trifluoromethyl Ether, O-TRIFLUOROMETHOXYPHENOL, 2-trifluoromethoxy phenol, MFCD00236324, trifluoromethoxyphenol, 2-(trifluormethoxy)phenol, Phenol, 2-(trifluoromethoxy)-, Trifluoromethoxy phenol, o-trifluoromethoxy phenol, 2-trifluoromethoxy-phenol, 2-(trifluoromethyloxy)phenol, SCHEMBL225016, SCHEMBL364380, SCHEMBL12504933, SCHEMBL16953264, SCHEMBL21268185, BCP27397, SBB089363, AKOS005257929, CS-W017348, PS-8564, 2-(Trifluoromethoxy)phenol, AldrichCPR, AC-17472, BP-11107, SY020774, DB-023897, ST50407135, T2156, EN300-133018, O10542, 2-Hydroxyphenyl Trifluoromethyl Ether;O-trifluoromethoxy phenol

2-(Trifluoromethoxy)phenol serves as a key intermediate in the synthesis of bioactive molecules, particularly in the development of pharmaceuticals and agrochemicals. Its trifluoromethoxy group is valuable for modulating lipophilicity and metabolic stability in drug candidates. Researchers also employ it in material science for designing advanced polymers and coatings with enhanced chemical resistance. Always handle under fume hood conditions using appropriate PPE.

Safety and Hazards

GHS Hazard Statements

• H226 (22.2%): Flammable liquid and vapor [Warning Flammable liquids]
• H301 (11.1%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302+H312+H332 (11.1%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (11.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (11.1%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (11.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (77.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (11.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H319 (88.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (11.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (55.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H412 (11.1%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (22.2%)
• Acute Tox. 3 (11.1%)
• Acute Tox. 4 (11.1%)
• Acute Tox. 4 (11.1%)
• Skin Irrit. 2 (77.8%)
• Skin Sens. 1 (11.1%)
• Eye Irrit. 2 (88.9%)
• Acute Tox. 4 (11.1%)
• STOT SE 3 (55.6%)
• Aquatic Chronic 3 (11.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.