Description

2-(Trifluoromethoxy)aniline (CAS No. 1535-75-7) is a high-purity aromatic amine derivative with the molecular formula C₇H₆F₃NO. This compound features a trifluoromethoxy (-OCF₃) group ortho to an amino (-NH₂) substituent on a benzene ring, offering unique electronic and steric properties for advanced synthetic applications. With a molecular weight of 177.12 g/mol, it is a versatile building block in pharmaceutical, agrochemical, and materials science research. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for nucleophilic substitutions, cross-coupling reactions, and as a precursor for heterocyclic compounds.

Properties

• CAS Number: 1535-75-7
• Complexity: 148
• IUPAC Name: 2-(trifluoromethoxy)aniline
• InChI: InChI=1S/C7H6F3NO/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4H,11H2
• InChI Key: ZFCOUBUSGHLCDT-UHFFFAOYSA-N
• Exact Mass: 177.04014830
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.12
• SMILES: C1=CC=C(C(=C1)N)OC(F)(F)F
• Topological: 35.3
• Monoisotopic Mass: 177.04014830
• Synonyms: 2-(Trifluoromethoxy)aniline, 1535-75-7, 2-trifluoromethoxyaniline, EINECS 216-257-9, DTXSID20165342, DTXCID3087833, 216-257-9, Benzenamine, 2-(trifluoromethoxy)-, 2-Trifluoromethoxy-phenylamine, MFCD00035959, o-trifluoromethoxyaniline, 2-(trifluoromethoxy)phenylamine, (2-(trifluoromethoxy)phenyl)amine, [2-(trifluoromethoxy)phenyl]amine, o-(trifluoromethoxy)aniline, alpha,alpha,alpha-Trifluoro-o-anisidine, C6X2TPD2ES, a,a,a-Trifluoro-o-anisidine, o-aminotrifluoromethoxybenzene, aniline, 2-trifluoromethoxy-, 2-(Trifluoromethyloxy)aniline, SCHEMBL112134, o-(trifluoromethoxy)phenylamine, 2-(Trifluoromethoxy)aniline #, 2-(Trifluoromethoxy)benzenamine, SCHEMBL2094741, SCHEMBL5126421, SCHEMBL9900543, SCHEMBL27973620, SCHEMBL28266828, 2-(Trifluoromethoxy)aniline, 95%, BBL027920, SBB006602, STK802606, AKOS001434625, CS-W017378, FT36754, PS-8571, SDCCGMLS-0066223.P001, AC-13393, o-Anisidine, alpha,alpha,alpha-trifluoro-, SY004061, DB-023752, NS00048297, ST50405159, T2145, EN300-23629, F2158-1062

Application

2-(Trifluoromethoxy)aniline is widely used as a key intermediate in the synthesis of bioactive molecules, particularly in pharmaceuticals and crop protection agents. Its electron-withdrawing trifluoromethoxy group enhances the reactivity of the aniline moiety in palladium-catalyzed couplings (e.g., Buchwald-Hartwig amination). Researchers also employ it to develop liquid crystals and OLED materials due to its unique polarizability. In medicinal chemistry, it serves as a scaffold for kinase inhibitors and CNS-targeting compounds.

Safety and Hazards

GHS Hazard Statements

• H226 (89.6%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H373 (10.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (89.6%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (87.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.