Description

2-Nitro-5-(trifluoromethoxy)aniline (CAS No. 2267-22-3) is a high-purity specialty chemical with the molecular formula C₇H₅F₃N₂O₃. This compound is characterized by its aniline core functionalized with a nitro group at the 2-position and a trifluoromethoxy group at the 5-position, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its unique structure offers excellent reactivity for further derivatization, particularly in the development of agrochemicals, dyes, and advanced materials. Available in >98% purity (HPLC), it is supplied as a crystalline solid with strict quality control to ensure consistency for research and industrial applications. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 2267-22-3
• Complexity: 241
• IUPAC Name: 2-nitro-5-(trifluoromethoxy)aniline
• InChI: InChI=1S/C7H5F3N2O3/c8-7(9,10)15-4-1-2-6(12(13)14)5(11)3-4/h1-3H,11H2
• InChI Key: DZYJIFLWGHFMGB-UHFFFAOYSA-N
• Exact Mass: 222.02522651
• Molecular Formula: C7H5F3N2O3
• Molecular Weight: 222.12
• SMILES: C1=CC(=C(C=C1OC(F)(F)F)N)[N+](=O)[O-]
• Topological: 81.1
• Monoisotopic Mass: 222.02522651
• Synonyms: 2-Nitro-5-(trifluoromethoxy)aniline, 2267-22-3, SCHEMBL14322739, DZYJIFLWGHFMGB-UHFFFAOYSA-N, SB80127

Application

2-Nitro-5-(trifluoromethoxy)aniline is primarily used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals due to its reactive nitro and trifluoromethoxy groups. It serves as a building block for heterocyclic compounds and fluorinated derivatives, which are critical in drug discovery and crop protection. Researchers also utilize it in material science for developing specialty polymers and dyes with enhanced thermal and chemical resistance.

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