Description

2-Naphthalenesulfonyl Chloride (CAS No. 93-11-8) is a high-purity organic sulfonyl chloride compound with the molecular formula C₁₀H₇ClO₂S. This reagent is widely utilized in organic synthesis, particularly as a sulfonylation agent for introducing the naphthalene-2-sulfonyl moiety into target molecules. The product is supplied as a crystalline solid with exceptional reactivity, making it ideal for peptide coupling, polymer modification, and pharmaceutical intermediate synthesis. Its IUPAC name is naphthalene-2-sulfonyl chloride, and it is rigorously tested for consistency in purity (>98%) and stability under recommended storage conditions (2-8°C, inert atmosphere). Suitable for research, industrial applications, and fine chemical production, this compound is packaged under nitrogen to ensure prolonged shelf life and optimal performance.

Properties

• CAS Number: 93-11-8
• Complexity: 294
• IUPAC Name: naphthalene-2-sulfonyl chloride
• InChI: InChI=1S/C10H7ClO2S/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H
• InChI Key: OPECTNGATDYLSS-UHFFFAOYSA-N
• Exact Mass: 225.9855283
• Molecular Formula: C10H7ClO2S
• Molecular Weight: 226.68
• SMILES: C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)Cl
• Topological: 42.5
• Monoisotopic Mass: 225.9855283
• Synonyms: 2-Naphthalenesulfonyl chloride, Naphthalene-2-sulfonyl chloride, 93-11-8, 2-Naphthylsulfonyl chloride, beta-Naphthalenesulfonyl chloride, Naphthalene-2-sulfonic acid chloride, beta-Naphthalenesulfochloride, .beta.-Naphthalenesulfochloride, NSC 133893, 2-Naphthalenylsulfonyl chloride, .beta.-Naphthalenesulfonyl chloride, EINECS 202-219-9, beta-Naphthylsulfonyl chloride, .beta.-Naphthylsulfonyl chloride, beta-Naphthalenesulfonyl-chloride, DTXSID5059080, OPECTNGATDYLSS-UHFFFAOYSA-, DTXCID6048830, inchi=1/c10h7clo2s/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7h, opectngatdylss-uhfffaoysa-n, MFCD00004087, 2-naphthalenesulphonyl chloride, NAPHTHALENE-2-SULPHONYL CHLORIDE, naphthalene-2-sulfonylchloride, W3N8WRJ279, 2-Naphthalene sulfonyl chloride, NSC-133893, chloro-2-naphthylsulfone, 2-Naphthalenylsulfonyl Chloride; 2-Naphthylsulfonyl Chloride;NSC 133893; Naphthalene-2-sulfonic Acid Chloridebeta-Naphthalenesulfochloride, ss-Naphthalinsulfochlorid, 2-naphtylsulfonyl chloride, 2-napthylsulfonyl chloride, 2-napthalenesufonylchloride, 2-naphtalenesulfonylchloride, 2-napthalenesulfonylchloride, 2-naphthylsulphonyl chloride, 2-Naphthalenesulfonylchloride, 2-naphthyl-sulfonyl chloride, UNII-W3N8WRJ279, 2-naphtalenesulfonyl chloride, 2-Naphthyl sulfonyl chloride, 2-napthalenesulfonyl chloride, beta-Naphthalenesulphochloride, SCHEMBL25642, 2-naphthalenylsulfonylchloride, 2-naphthyl-sulphonyl chloride, 2-naphthalene sulfonylchloride, 2-naphthalenesulfonyi chloride, beta-Naphthylsulphonyl chloride, 2-naphthalene-sulfonyl chloride, 2-naphthalene-sulphonyl chloride, beta-Naphthalenesulphonyl chloride, beta-naphthalene-sulphonyl chloride, naphthalin-2-sulfonic acid chloride, naphthaline-2-sulfonic acid chloride, 2-Naphthalenesulfonyl chloride, 99%, BBL027447, NSC133893, SBB032961, STL363253, AKOS000118779, CS-W004905, FN07833, VS-0375, DB-057370, N0018, NS00041120, ST51037637, EN300-19464, D77675, A844453, F0808-2035, Z104473932, 2-Naphthalenesulfonyl chloride, puriss., >=99.0% (AT)

Application

2-Naphthalenesulfonyl chloride is primarily used as a sulfonylation reagent in organic synthesis, enabling the introduction of sulfonyl groups into amines, alcohols, and other nucleophiles. It serves as a key intermediate in the preparation of dyes, pharmaceuticals, and agrochemicals. Researchers also employ it in peptide chemistry for protecting-group strategies and polymer functionalization due to its high reactivity and selectivity.

Safety and Hazards

GHS Hazard Statements

• H314 (80.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (19.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H411 (19.7%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P260, P264, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P332+P317, P362+P364, P363, P391, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (80.3%)
• Skin Irrit. 2 (19.7%)
• Aquatic Chronic 2 (19.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.