Description

Description

2-(Methylsulfonyl)oxirane (CAS No. 1039122-77-4) is a high-purity sulfonyl-functionalized oxirane compound with the molecular formula C₃H₆O₃S. This specialized epoxide derivative features a reactive methylsulfonyl group adjacent to the strained oxirane ring, making it a valuable electrophilic intermediate for advanced organic synthesis and medicinal chemistry applications. The compound is supplied as a stable solid with >95% purity (HPLC), rigorously tested for consistency in batch-to-batch performance. Ideal for nucleophilic ring-opening reactions, cross-coupling methodologies, and as a building block for sulfone-containing pharmacophores. Packaged under inert atmosphere in amber glass vials with PTFE-lined caps to ensure long-term stability.

Key Specifications:
– Molecular Weight: 122.14 g/mol
– IUPAC Name: 2-methylsulfonyloxirane
– Storage Conditions: 2-8??C under inert atmosphere
– Hazard Class: Corrosive (GHS05), Skin Sensitizer (GHS09)

Application

2-(Methylsulfonyl)oxirane serves as a versatile synthon in pharmaceutical intermediate synthesis, particularly for introducing sulfone moieties into bioactive molecules. The compound’s strained epoxide ring undergoes regioselective opening with nucleophiles, enabling creation of ??-hydroxy sulfones with structural diversity. Researchers utilize this reagent in proteomics studies as an electrophilic modifier for cysteine residues. Recent applications include development of covalent kinase inhibitors and as a precursor for sulfone-containing epoxy resins with enhanced thermal stability.

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