Description

(2-Methylpropyl)boronic acid (CAS No. 84110-40-7) is a high-purity organoboron compound with the molecular formula C₄H₁₁BO₂, widely utilized in organic synthesis and pharmaceutical research. This white to off-white crystalline solid is characterized by its boronic acid functional group, which enables versatile reactivity in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern C-C bond formation. With an IUPAC name of 2-methylpropylboronic acid, it is also known by synonyms such as Isobutylboronic Acid. Our product is rigorously tested for purity (typically ≥95% by HPLC or NMR) and is supplied under inert conditions to ensure stability. Ideal for researchers in medicinal chemistry, material science, and catalysis, this reagent is packaged in amber glass vials or sealed bags to prevent moisture absorption and degradation. Always handle under nitrogen or argon to maintain integrity.

Properties

• CAS Number: 84110-40-7
• Complexity: 45
• IUPAC Name: isobutylboronic acid
• InChI: InChI=1S/C4H11BO2/c1-4(2)3-5(6)7/h4,6-7H,3H2,1-2H3
• InChI Key: ZAZPDOYUCVFPOI-UHFFFAOYSA-N
• Exact Mass: 102.0852098
• Molecular Formula: C4H11BO2
• Molecular Weight: 101.94
• SMILES: B(CC(C)C)(O)O
• Topological: 40.5
• Monoisotopic Mass: 102.0852098
• Synonyms: 2-Methylpropylboronic acid, (2-Methylpropyl)boronic acid, 617-531-4, Isobutylboronic Acid, 84110-40-7, Isobutaneboronic acid, isobutylboric acid, MFCD00134156, KHX76H7JHZ, 2-Methylpropane boronic acid, B-(2-Methylpropyl)boronic acid, Boronic acid, B-(2-methylpropyl)-, Boronic acid, (2-methylpropyl)-, 2-methylprop-1-ylboronic acid, IsobutylboronicAcid, Isobutyl boronic acid, 1-Isobutaneboronic Acid, Bortezomib Impurity N17, i-BuB(OH)2, UNII-KHX76H7JHZ, 2-methylpropaneboronic acid, 2-methylpropyl boronic acid, SCHEMBL125840, 2-Methyl-1-propylboronic acid, DTXSID70370282, ZAZPDOYUCVFPOI-UHFFFAOYSA-N, Isobutylboronic acid (contains varying amounts of Anhydride), BCP12813, SBB062832, AKOS000264708, AB03722, AS-3103, CS-W000978, FI11079, HY-W000978, AC-24794, SY002441, (2-Methylpropyl)boronic acid, >=95.0%, DB-010478, I0597, EN300-74361, F0001-2138, Z1098324138, B-(2-methylpropyl)boronic Acid; 2-Methyl-1-propaneboronic Acid; (2-Methylpropyl)boronic Acid; Isobutyl Boronic Acid; Isobutylboric Acid

Application

(2-Methylpropyl)boronic acid is a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of biaryl compounds for pharmaceuticals and agrochemicals. It serves as a building block in the development of boron-containing drugs, particularly protease inhibitors and kinase-targeted therapies. Researchers also employ it in polymer chemistry to create functionalized materials with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (92.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (92.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.