Description

Description

2-Methyl-5-nitro-1-{2-[(trimethylsilyl)oxy]ethyl}-1H-imidazole (CAS No. 89422-95-7) is a high-purity, synthetic nitroimidazole derivative with the molecular formula C₉H₁₇N₃O₃Si. This specialized organosilicon compound features a trimethylsilyl-protected hydroxyethyl group attached to the imidazole ring, enhancing its stability and reactivity in synthetic applications. With an IUPAC name of trimethyl-[2-(2-methyl-5-nitroimidazol-1-yl)ethoxy]silane, this compound is characterized by its nitro functional group at the 5-position and a methyl group at the 2-position of the imidazole core. The trimethylsilyl (TMS) ether moiety provides excellent protection for the hydroxyl group during complex organic syntheses. Supplied as a crystalline solid or powder with >95% purity (HPLC), this chemical is ideal for pharmaceutical research, medicinal chemistry, and advanced material science applications. Store under inert conditions at 2-8??C to maintain stability.

Application

This nitroimidazole derivative serves as a key intermediate in the synthesis of novel antimicrobial and antiprotozoal agents, particularly in the development of metronidazole analogs. The TMS-protected hydroxyethyl group allows for selective deprotection in multi-step synthetic routes. Researchers utilize this compound in nucleoside chemistry for modifying imidazole-containing scaffolds. Its nitro group participates in redox reactions important for prodrug activation studies.

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