Description

2-Methoxy-3-(trifluoromethyl)pyridine (CAS No. 121643-44-5) is a high-purity fluorinated pyridine derivative with the molecular formula C₇H₆F₃NO. This compound is a versatile building block in pharmaceutical, agrochemical, and materials science research, offering unique reactivity due to its trifluoromethyl and methoxy functional groups. Its IUPAC name is 2-methoxy-3-(trifluoromethyl)pyridine, and it is characterized by exceptional stability and compatibility with a wide range of synthetic conditions. Available in >98% purity (GC), this product is rigorously tested for consistency and supplied in sealed, light-resistant packaging to ensure long-term stability. Ideal for nucleophilic substitution reactions, cross-coupling methodologies, and as a ligand precursor.

Properties

• CAS Number: 121643-44-5
• Complexity: 148
• IUPAC Name: 2-methoxy-3-(trifluoromethyl)pyridine
• InChI: InChI=1S/C7H6F3NO/c1-12-6-5(7(8,9)10)3-2-4-11-6/h2-4H,1H3
• InChI Key: SSAZZVQVJJXPMB-UHFFFAOYSA-N
• Exact Mass: 177.04014830
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.12
• SMILES: COC1=C(C=CC=N1)C(F)(F)F
• Topological: 22.1
• Monoisotopic Mass: 177.04014830
• Synonyms: 2-Methoxy-3-(trifluoromethyl)pyridine, 121643-44-5, DTXSID70923914, DTXCID801352761, 625-462-6, 2-Methoxy-3-Trifluoromethylpyridine, Pyridine, 2-methoxy-3-(trifluoromethyl)-, MFCD00153202, SCHEMBL322870, SCHEMBL932929, SCHEMBL4512844, 2-methoxy-3-trifluoromethyl-pyridine, SBB055545, 3-(trifluoromethyl)-2-methoxypyridine, AKOS005063435, AC-9483, CS-W002446, FS-1130, SY008261, DB-027041, 2-Methoxy-3-(trifluoromethyl)pyridine, 96%, M2191, ST50407160

Application

2-Methoxy-3-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of bioactive molecules, particularly in the development of pharmaceuticals and crop protection agents. Its trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable in drug discovery. Researchers utilize this compound in palladium-catalyzed cross-coupling reactions to construct complex heterocycles. It is also employed in material science for designing fluorinated liquid crystals or electronic materials due to its electron-withdrawing properties.

Safety and Hazards

GHS Hazard Statements

• H226 (88.9%): Flammable liquid and vapor [Warning Flammable liquids]
• H300 (86.7%): Fatal if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (88.9%)
• Acute Tox. 2 (86.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.