Description

2-Methoxy-3-nitropyridine (CAS: 20265-35-4) is a high-purity nitropyridine derivative with the molecular formula C₆H₆N₂O₃. This compound is an essential intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of novel active ingredients. Its unique structure, featuring a methoxy group at the 2-position and a nitro group at the 3-position of the pyridine ring, enables versatile reactivity in nucleophilic aromatic substitution and reduction reactions. With a purity of ≥97%, this product is rigorously tested via HPLC, GC, and NMR to ensure consistency for research and industrial applications. It is supplied as a crystalline solid with excellent shelf stability under recommended storage conditions (2-8°C, inert atmosphere). Ideal for medicinal chemistry, material science, and cross-coupling reactions.

Properties

• CAS Number: 20265-35-4
• Complexity: 145
• IUPAC Name: 2-methoxy-3-nitro-pyridine
• InChI: InChI=1S/C6H6N2O3/c1-11-6-5(8(9)10)3-2-4-7-6/h2-4H,1H3
• InChI Key: WZNQCVOSOCGWJG-UHFFFAOYSA-N
• Exact Mass: 154.03784206
• Molecular Formula: C6H6N2O3
• Molecular Weight: 154.12
• SMILES: COC1=C(C=CC=N1)[N+](=O)[O-]
• Topological: 67.9
• Monoisotopic Mass: 154.03784206
• Synonyms: 2-Methoxy-3-nitropyridine, DTXSID90942384, DTXCID001370787, 654-159-1, wznqcvosocgwjg-uhfffaoysa-n, 20265-35-4, 2-methoxy-3-nitro-pyridine, MFCD00023459, Pyridine, 2-methoxy-3-nitro-, NSC75835, Maybridge1_008636, SCHEMBL231110, SCHEMBL2067164, SCHEMBL2068080, SCHEMBL17339157, HMS566A12, 2-Methoxy-3-nitropyridine, 97%, CCG-51466, NSC-75835, SBB065303, AKOS005086440, AC-5399, CS-W018056, DS-1340, FM07068, SB52485, METHYL 3-NITRO-2-PYRIDINYL ETHER, SY032655, M1395, ST50409762, 2R-0668, AC-907/34117017, SR-01000640762-1

2-Methoxy-3-nitropyridine serves as a key building block in the synthesis of heterocyclic compounds, particularly in pharmaceutical research for antitumor and antimicrobial agents. It is widely used in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to introduce nitropyridine motifs into complex molecules. Additionally, this compound finds utility in agrochemical development as a precursor for herbicides and insecticides. Its nitro group can be selectively reduced to amines or converted into other functional groups, enabling diverse derivatization strategies.

Safety and Hazards

GHS Hazard Statements

• H302 (88.4%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (88.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (88.4%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (88.4%)
• Eye Irrit. 2 (11.6%)
• STOT SE 3 (97.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.