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Atomfair 2-Methoxy-3-nitropyridine C6H6N2O3 CAS 20265-35-4

2-Methoxy-3-nitropyridine (CAS: 20265-35-4) is a high-purity nitropyridine derivative with the molecular formula C6H6N2O3. This compound is an essential intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of novel active ingredients. Its unique structure, featuring a methoxy group at the 2-position and a nitro group at the 3-position of the pyridine ring, enables versatile reactivity in nucleophilic aromatic substitution and reduction reactions. With a purity of ≥97%, this product is rigorously tested via HPLC, GC, and NMR to ensure consistency for research and industrial applications. It is supplied as a crystalline solid with excellent shelf stability under recommended storage…

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Description

2-Methoxy-3-nitropyridine (CAS: 20265-35-4) is a high-purity nitropyridine derivative with the molecular formula C6H6N2O3. This compound is an essential intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of novel active ingredients. Its unique structure, featuring a methoxy group at the 2-position and a nitro group at the 3-position of the pyridine ring, enables versatile reactivity in nucleophilic aromatic substitution and reduction reactions. With a purity of ≥97%, this product is rigorously tested via HPLC, GC, and NMR to ensure consistency for research and industrial applications. It is supplied as a crystalline solid with excellent shelf stability under recommended storage conditions (2-8°C, inert atmosphere). Ideal for medicinal chemistry, material science, and cross-coupling reactions.

Properties

  • CAS Number: 20265-35-4
  • Complexity: 145
  • IUPAC Name: 2-methoxy-3-nitro-pyridine
  • InChI: InChI=1S/C6H6N2O3/c1-11-6-5(8(9)10)3-2-4-7-6/h2-4H,1H3
  • InChI Key: WZNQCVOSOCGWJG-UHFFFAOYSA-N
  • Exact Mass: 154.03784206
  • Molecular Formula: C6H6N2O3
  • Molecular Weight: 154.12
  • SMILES: COC1=C(C=CC=N1)[N+](=O)[O-]
  • Topological: 67.9
  • Monoisotopic Mass: 154.03784206
  • Synonyms: 2-Methoxy-3-nitropyridine, DTXSID90942384, DTXCID001370787, 654-159-1, wznqcvosocgwjg-uhfffaoysa-n, 20265-35-4, 2-methoxy-3-nitro-pyridine, MFCD00023459, Pyridine, 2-methoxy-3-nitro-, NSC75835, Maybridge1_008636, SCHEMBL231110, SCHEMBL2067164, SCHEMBL2068080, SCHEMBL17339157, HMS566A12, 2-Methoxy-3-nitropyridine, 97%, CCG-51466, NSC-75835, SBB065303, AKOS005086440, AC-5399, CS-W018056, DS-1340, FM07068, SB52485, METHYL 3-NITRO-2-PYRIDINYL ETHER, SY032655, M1395, ST50409762, 2R-0668, AC-907/34117017, SR-01000640762-1

2-Methoxy-3-nitropyridine serves as a key building block in the synthesis of heterocyclic compounds, particularly in pharmaceutical research for antitumor and antimicrobial agents. It is widely used in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to introduce nitropyridine motifs into complex molecules. Additionally, this compound finds utility in agrochemical development as a precursor for herbicides and insecticides. Its nitro group can be selectively reduced to amines or converted into other functional groups, enabling diverse derivatization strategies.

Safety and Hazards

GHS Hazard Statements

  • H302 (88.4%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (88.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H319 (11.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (88.4%)
  • Skin Irrit. 2 (100%)
  • Eye Dam. 1 (88.4%)
  • Eye Irrit. 2 (11.6%)
  • STOT SE 3 (97.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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