Description

2-Mercaptopyridine (CAS No. 2637-34-5) is a high-purity heterocyclic organosulfur compound with the molecular formula C₅H₅NS. Also known as 1H-pyridine-2-thione by IUPAC nomenclature, this versatile reagent features a reactive thiol (-SH) group adjacent to a pyridine ring, enabling its use as a ligand, catalyst, or intermediate in organic synthesis and coordination chemistry. Available in crystalline form (typically >98% purity by HPLC), it exhibits excellent solubility in polar organic solvents such as ethanol, DMSO, and acetone. Ideal for pharmaceutical research, materials science, and chemical catalysis, our 2-mercaptopyridine is rigorously tested for consistency, with batch-specific analytical certificates (GC/MS, NMR) provided. Store under inert atmosphere at 2-8°C to prevent oxidation. Suitable for click chemistry, metal complexation, and as a building block for bioactive molecules.

Properties

• CAS Number: 2637-34-5
• Complexity: 135
• IUPAC Name: 1H-pyridine-2-thione
• InChI: InChI=1S/C5H5NS/c7-5-3-1-2-4-6-5/h1-4H,(H,6,7)
• InChI Key: WHMDPDGBKYUEMW-UHFFFAOYSA-N
• Exact Mass: 111.01427034
• Molecular Formula: C5H5NS
• Molecular Weight: 111.17
• SMILES: C1=CC(=S)NC=C1
• Topological: 44.1
• Monoisotopic Mass: 111.01427034
• Physical Description: Solid with a stench;
• Vapor Pressure: 0.00863 [mmHg]
• Synonyms: 2-Mercaptopyridine, Pyridine-2-thiol, 2637-34-5, 2-Pyridinethiol, 2-Thiopyridine, 73018-10-7, 1H-pyridine-2-thione, 2(1H)-PYRIDINETHIONE, Pyrid-2-thione, 2-Thiopyridone, 2-Pyridyl mercaptan, 2-pyridylthiol, Thiopyridone-2, 2-pyridinylthiol, Thiopyridone-2 [French], NSC 41337, CHEBI:45223, EINECS 220-131-9, EE982KT952, MERCAPTOPYRIDINE, 2-, DTXSID9062568, 2pyridinethiol, 2thiopyridine, Pyridine2thiol, Thiopyridone2, Pyrid2thione, pyridine-2-thione, 2(1H)Pyridinethione, DTXCID5037492, 220-131-9, 946-524-1, Pyridinethione, 2-Pyridinethione, 1,2-dihydropyridine-2-thione, pyridine-2(1H)-thione, 2-Mercapto pyridine, 29468-20-0, MFCD00006285, Alrithiol-2, C5H5NS, 2-Pyridinethiol; 2-Pyridinethione; 2-Pyridyl mercaptan; 2-Pyridylthiol; 2-Sulfanylpyridine, PYS, 2-mercapto-pyridine, thioxopyridine, mercaptopyridine, UNII-EE982KT952, 2-thioxopyridine, pyridin-2-thiol, pyridine-2-thio, Pridine-2-thiol, I+/–Thiopyridon, EINECS 249-657-7, pyridine, 2-mercapto-, Pyridin-2(1H)-thione, WLN: T6NJ BSH, Epitope ID:120365, SCHEMBL38243, SCHEMBL54576, SCHEMBL143433, SCHEMBL421873, SCHEMBL3062854, SCHEMBL4466845, SCHEMBL4470294, SCHEMBL4477763, SCHEMBL6272432, SCHEMBL7333734, SCHEMBL7361437, SCHEMBL7453608, SCHEMBL8018779, Thio-2-pyridine;2-Thiopyridine, CHEMBL1235541, SCHEMBL11350464, 2-mercaptopyridine (thione form), BCP21833, NSC41337, NSC-41337, SBB058593, STL281380, AKOS000120194, AKOS003596823, DB03329, FM07088, PS-6210, PD007080, SY009099, 2-Mercaptopyridine, ReagentPlus(R), 99%, DB-015976, CS-0020126, M0246, NS00028094, ST50701362, EN300-21547, E81838, A818409, A837693, 2-Mercaptopyridine, Vetec(TM) reagent grade, 98%, Q15274000, F9995-0226, Z203045372, 2637-34-5;2-Pyridinethiol;Pyridine-2-thiol;2-Thiopyridine

Application

2-Mercaptopyridine serves as a key precursor in the synthesis of metal-chelating agents and pharmaceutical intermediates. Its thiol group readily forms stable complexes with transition metals like palladium and platinum, making it valuable in catalytic systems. Researchers utilize this compound to modify surfaces for sensor development and to create heterocyclic scaffolds in medicinal chemistry. In materials science, it functions as a stabilizing ligand for nanoparticles and quantum dots.

Safety and Hazards

GHS Hazard Statements

• Not Classified
• Reported as not meeting GHS hazard criteria by 1 of 1 companies. For more detailed information, please visit ECHA C&L website.

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (98%)
• Eye Irrit. 2 (98%)
• STOT SE 3 (94.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.