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Atomfair 2-Iodo-4-methylpyridine C6H6IN CAS 22282-60-6

2-Iodo-4-methylpyridine (CAS No. 22282-60-6) is a high-purity halogenated pyridine derivative with the molecular formula C6H6IN . This organoiodine compound is a valuable intermediate in pharmaceutical and agrochemical synthesis, offering exceptional reactivity for cross-coupling reactions (e.g., Suzuki, Negishi). The methyl group at the 4-position enhances electron density, making it particularly useful for directed metalation and subsequent functionalization. Supplied as crystalline solid with ≥98% purity (HPLC), it is rigorously tested for heavy metals (<10 ppm) and residual solvents. Optimal storage at 2-8°C under inert atmosphere ensures long-term stability. Available in research (1g, 5g) and bulk (25g, 100g) quantities with COA/MSDS documentation.

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Description

2-Iodo-4-methylpyridine (CAS No. 22282-60-6) is a high-purity halogenated pyridine derivative with the molecular formula C6H6IN. This organoiodine compound is a valuable intermediate in pharmaceutical and agrochemical synthesis, offering exceptional reactivity for cross-coupling reactions (e.g., Suzuki, Negishi). The methyl group at the 4-position enhances electron density, making it particularly useful for directed metalation and subsequent functionalization. Supplied as crystalline solid with ≥98% purity (HPLC), it is rigorously tested for heavy metals (<10 ppm) and residual solvents. Optimal storage at 2-8°C under inert atmosphere ensures long-term stability. Available in research (1g, 5g) and bulk (25g, 100g) quantities with COA/MSDS documentation.

Properties

  • CAS Number: 22282-60-6
  • Complexity: 74.9
  • IUPAC Name: 2-iodo-4-methyl-pyridine
  • InChI: InChI=1S/C6H6IN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
  • InChI Key: DZFWKQYMUZMLSR-UHFFFAOYSA-N
  • Exact Mass: 218.95450
  • Molecular Formula: C6H6IN
  • Molecular Weight: 219.02
  • SMILES: CC1=CC(=NC=C1)I
  • Topological: 12.9
  • Monoisotopic Mass: 218.95450
  • Synonyms: 2-Iodo-4-methylpyridine, 22282-60-6, DTXSID40494782, DTXCID40445592, 843-955-6, Pyridine, 2-iodo-4-methyl-, 4-Methyl-2-iodopyridine, MFCD12963767, 2-Iodo-4-picoline, SCHEMBL4008373, XAA28260, AKOS015891955, AS-82640, CS-0436352, D87895, EN300-1666252

Application

2-Iodo-4-methylpyridine serves as a key building block in palladium-catalyzed cross-coupling reactions for drug discovery, particularly in synthesizing kinase inhibitors and antiviral compounds. The iodine moiety enables efficient Sonogashira couplings for alkyne-functionalized heterocycles. In material science, it acts as precursor for N-donor ligands in catalytic systems. The methyl group facilitates C-H activation in late-stage diversification of pharmaceutical intermediates.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • Acute Tox. 4 (100%)
  • STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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