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Atomfair 2-Hydroxy-6-methyl-3-nitropyridine C6H6N2O3 CAS 39745-39-6

2-Hydroxy-6-methyl-3-nitropyridine (CAS No. 39745-39-6) is a high-purity nitropyridine derivative with the molecular formula C6H6N2O3, widely used in pharmaceutical and agrochemical research. This compound, also known by its IUPAC name 6-methyl-3-nitro-1H-pyridin-2-one , features a nitro group at the 3-position and a hydroxyl group at the 2-position of the pyridine ring, making it a versatile intermediate for heterocyclic synthesis. It is supplied as a fine crystalline powder with ≥98% purity (HPLC), ensuring optimal performance in nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for bioactive molecules. Each batch undergoes rigorous QC testing including1H/13C NMR, LC-MS, and elemental analysis to guarantee structural…

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Description

2-Hydroxy-6-methyl-3-nitropyridine (CAS No. 39745-39-6) is a high-purity nitropyridine derivative with the molecular formula C6H6N2O3, widely used in pharmaceutical and agrochemical research. This compound, also known by its IUPAC name 6-methyl-3-nitro-1H-pyridin-2-one, features a nitro group at the 3-position and a hydroxyl group at the 2-position of the pyridine ring, making it a versatile intermediate for heterocyclic synthesis. It is supplied as a fine crystalline powder with ≥98% purity (HPLC), ensuring optimal performance in nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for bioactive molecules. Each batch undergoes rigorous QC testing including 1H/13C NMR, LC-MS, and elemental analysis to guarantee structural integrity. Packaged under inert gas in amber glass vials with PTFE-lined caps to prevent degradation. Suitable for medicinal chemistry, material science, and as a building block for fluorescent dyes.

Properties

  • CAS Number: 39745-39-6
  • Complexity: 272
  • IUPAC Name: 6-methyl-3-nitro-1H-pyridin-2-one
  • InChI: InChI=1S/C6H6N2O3/c1-4-2-3-5(8(10)11)6(9)7-4/h2-3H,1H3,(H,7,9)
  • InChI Key: YVYDGIGILRUPED-UHFFFAOYSA-N
  • Exact Mass: 154.03784206
  • Molecular Formula: C6H6N2O3
  • Molecular Weight: 154.12
  • SMILES: CC1=CC=C(C(=O)N1)[N+](=O)[O-]
  • Topological: 74.9
  • Monoisotopic Mass: 154.03784206
  • Synonyms: 39745-39-6, 2-Hydroxy-6-methyl-3-nitropyridine, DTXSID90337478, DTXCID80288566, 625-238-8, yvydgigilruped-uhfffaoysa-n, 6-methyl-3-nitropyridin-2-ol, 6-Hydroxy-5-nitro-2-picoline, 6-methyl-3-nitro-2(1h)-pyridinone, 2-hydroxy-3-nitro-6-methylpyridine, 6-methyl-3-nitro-1H-pyridin-2-one, MFCD03001414, 6-methyl-3-nitro-1,2-dihydropyridin-2-one, 6-methyl-3-nitropyridin-2(1h)-one, 2-Hydroxy-3-nitro-6-picoline, 6-Methyl-3-nitro-2-pyridone, SCHEMBL801581, 3-nitro-6-methylpyridin-2-ol, 6-Methyl-3-nitro-2-pyridinol, SCHEMBL8114255, 6-Methyl-3-nitro-2-pyridinol #, ALBB-032184, BCP22177, 2-Hydroxy-3-nitro-6-picoline (2-Hydroxy-6-methyl-3-nitropyridine), GEO-01529, SBB065292, AKOS005255472, AKOS006281416, AB12817, CCG-321193, CS-W018057, PS-5379, AC-23066, SY011619, 2-Hydroxy-6-methyl-3-nitropyridine, 97%, DB-021195, H1498, EN300-111190, N11927, AN-228/40173369, Z1436472854, 6-Hydroxy-5-nitro-2-picoline ;2-Hydroxy-6-methyl-3-nitropyridine

Application

2-Hydroxy-6-methyl-3-nitropyridine serves as a key synthon in the development of kinase inhibitors and antimicrobial agents due to its electron-deficient pyridine core. Researchers utilize this compound as a scaffold for designing novel PET radiotracers, leveraging its nitro group for 18F-radiolabeling. In material science, it functions as a ligand precursor for transition metal complexes in catalytic systems. The compound’s unique substitution pattern also enables its use in constructing fused heterocycles for optoelectronic applications.

Safety and Hazards

GHS Hazard Statements

  • H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (97.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (97.6%)
  • Skin Irrit. 2 (100%)
  • Eye Dam. 1 (97.6%)
  • STOT SE 3 (97.6%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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