Description

Description

2-Hydroxy-6-methyl-3-nitropyridine (CAS No. 39745-39-6) is a high-purity nitropyridine derivative with the molecular formula C₆H₆N₂O₃, widely used in pharmaceutical and agrochemical research. This compound, also known by its IUPAC name 6-methyl-3-nitro-1H-pyridin-2-one, features a nitro group at the 3-position and a hydroxyl group at the 2-position of the pyridine ring, making it a versatile intermediate for heterocyclic synthesis. It is supplied as a fine crystalline powder with ??98% purity (HPLC), ensuring optimal performance in nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for bioactive molecules. Each batch undergoes rigorous QC testing including ¹H/¹³C NMR, LC-MS, and elemental analysis to guarantee structural integrity. Packaged under inert gas in amber glass vials with PTFE-lined caps to prevent degradation. Suitable for medicinal chemistry, material science, and as a building block for fluorescent dyes.

Application

2-Hydroxy-6-methyl-3-nitropyridine serves as a key synthon in the development of kinase inhibitors and antimicrobial agents due to its electron-deficient pyridine core. Researchers utilize this compound as a scaffold for designing novel PET radiotracers, leveraging its nitro group for ¹⁸F-radiolabeling. In material science, it functions as a ligand precursor for transition metal complexes in catalytic systems. The compound’s unique substitution pattern also enables its use in constructing fused heterocycles for optoelectronic applications.

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