Description

2-Fluoropyridine-5-carbonyl chloride (CAS No. 65352-94-5) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₃ClFNO. This reactive acyl chloride is a versatile building block in organic synthesis, particularly for the introduction of the 6-fluoronicotinoyl moiety. The compound is characterized by its pale to colorless appearance and is typically supplied as a neat liquid or solution. With a molecular weight of 159.54 g/mol, it offers excellent reactivity for nucleophilic substitution reactions. Suitable for use under inert atmosphere, this product is ideal for pharmaceutical intermediates, agrochemical synthesis, and materials science applications. Store in tightly sealed containers under dry, cool conditions to maintain stability.

Properties

• CAS Number: 65352-94-5
• Complexity: 142
• IUPAC Name: 6-fluoropyridine-3-carbonyl chloride
• InChI: InChI=1S/C6H3ClFNO/c7-6(10)4-1-2-5(8)9-3-4/h1-3H
• InChI Key: IPOCOANFUVSCLZ-UHFFFAOYSA-N
• Exact Mass: 158.9887196
• Molecular Formula: C6H3ClFNO
• Molecular Weight: 159.54
• SMILES: C1=CC(=NC=C1C(=O)Cl)F
• Topological: 30
• Monoisotopic Mass: 158.9887196
• Synonyms: 2-Fluoropyridine-5-carbonyl chloride, 687-741-9, 65352-94-5, 6-fluoropyridine-3-carbonyl chloride, 6-fluoronicotinoyl chloride, 3-Pyridinecarbonyl chloride, 6-fluoro- (9CI), MFCD07781233, 2-Fluoropyridine-5-carbonyl chloride (~80%), 6-Fluoro-nicotinoyl chloride, 3-PYRIDINECARBONYL CHLORIDE, 6-FLUORO-, 6-fluoronicotinoylchloride, SCHEMBL691934, 6-fluoro nicotinic acid chloride, DTXSID50562325, IPOCOANFUVSCLZ-UHFFFAOYSA-N, SBB087392, AKOS006343269, AB42627, AC-33911, AS-40834, SY064677, EN300-256329, 2-Fluoropyridine-5-carbonyl chloride, 6-Fluoropyridine-3-carbonyl chloride, 5-(Chlorocarbonyl)-2-fluoropyridine

Application

2-Fluoropyridine-5-carbonyl chloride serves as a key intermediate in the synthesis of fluorinated pyridine derivatives with applications in pharmaceutical research. It is particularly valuable in the preparation of active pharmaceutical ingredients (APIs) and agrochemicals. The compound’s reactivity makes it suitable for amide bond formation in peptide mimetics and enzyme inhibitors. Researchers also utilize it in material science for creating specialized fluorinated polymers.

Safety and Hazards

GHS Hazard Statements

• H227 (40%): Combustible liquid [Warning Flammable liquids]
• H302 (80%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (20%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H317 (20%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H332 (20%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (40%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P260, P261, P264, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (40%)
• Acute Tox. 4 (80%)
• Acute Tox. 4 (20%)
• Skin Corr. 1B (100%)
• Skin Sens. 1 (20%)
• Acute Tox. 4 (20%)
• STOT SE 3 (40%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.