Description

2-Fluoropyridine-4-boronic acid (CAS No. 401815-98-3) is a high-purity boronic acid derivative with the molecular formula C₅H₅BFNO₂ and IUPAC name (2-fluoropyridin-4-yl)boronic acid. This compound is a valuable building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its reactive boronic acid functional group and fluorinated pyridine backbone. It is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ensuring optimal performance in research and industrial applications. Suitable for use in pharmaceutical, agrochemical, and materials science research, this reagent is rigorously tested for quality, stability, and consistency. Store under inert conditions at 2-8°C to maintain stability.

Properties

• CAS Number: 401815-98-3
• Complexity: 114
• IUPAC Name: (2-fluoro-4-pyridyl)boronic acid
• InChI: InChI=1S/C5H5BFNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3,9-10H
• InChI Key: WXGBZJJAGLSBPR-UHFFFAOYSA-N
• Exact Mass: 141.0397367
• Molecular Formula: C5H5BFNO2
• Molecular Weight: 140.91
• SMILES: B(C1=CC(=NC=C1)F)(O)O
• Topological: 53.4
• Monoisotopic Mass: 141.0397367
• Synonyms: 2-Fluoropyridine-4-boronic acid, 401815-98-3, DTXSID40382635, DTXCID20333660, 640-138-4, (2-fluoropyridin-4-yl)boronic Acid, 2-fluoropyridin-4-ylboronic acid, 2-Fluoro-4-pyridineboronic acid, MFCD04112534, 2-FLUOROPYRIDIN-4-YL-4-BORONIC ACID, 2-Fluoro-4-pyridinylboronic acid, (2-fluoro-4-pyridyl)boronic acid, 2-fluoro-pyridine-4-boronic acid, BORONIC ACID, (2-FLUORO-4-PYRIDINYL)-, (2-fluoro-4-pyridinyl)boronic acid, SCHEMBL155221, 2-fluoropyridine4-boronic acid, 2-fluoro-4-pyridinylboronicacid, CHEMBL3236586, 2-fluoro-4-pyridine boronic acid, 2-fluoro-4-pyridine-boronic acid, WXGBZJJAGLSBPR-UHFFFAOYSA-N, 2-fluoro-pyridin-4-ylboronic acid, 2-fluoropyridin-4-yl-boronic acid, (2-fluoropyridin-4-yl)boronicAcid, BCP22988, CS-D1044, 2-fluoro-pyridin-4-yl-boronic acid, BBL101411, RB2041, SBB071113, STL555207, AKOS005258738, 2-FLUORO-4-PYRIDYLBORONIC ACID, AB17600, AC-6985, GS-6566, BP-10997, HY-32951, SY013200, DB-008200, 2-fluoropyridine-4-boronic acid, AldrichCPR, F0935, EN300-170324, Z1201622775

Application

2-Fluoropyridine-4-boronic acid is widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds for pharmaceuticals and agrochemicals. Its fluorinated pyridine moiety enhances metabolic stability and bioavailability in drug discovery. Researchers also employ it in the development of advanced materials, such as organic electronic components and metal-organic frameworks (MOFs).

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (88.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (88.9%)

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