Description

2-Fluorophenol (CAS No. 367-12-4) is a fluorinated aromatic compound with the molecular formula C₆H₅FO. This high-purity reagent is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique reactivity as an electron-deficient phenol derivative. The ortho-fluorine substitution imparts distinct electronic and steric properties, making it valuable for Suzuki couplings, nucleophilic aromatic substitutions, and as a building block for advanced intermediates.

Our 2-Fluorophenol is rigorously quality-controlled via GC/HPLC and NMR to ensure ≥98% purity (typical ≥99%), with stringent limits on moisture and heavy metals. Supplied in amber glass bottles under inert atmosphere to prevent degradation, it’s ideal for sensitive applications. Available in quantities from 1g to 5kg with custom packaging options.

Key Specifications:
– Molecular Weight: 112.10 g/mol
– Melting Point: 14-16°C
– Boiling Point: 171-172°C
– Density: 1.226 g/mL at 25°C
– Refractive Index: n²⁰_D 1.504-1.506

Properties

• CAS Number: 367-12-4
• Complexity: 74.9
• IUPAC Name: 2-fluorophenol
• InChI: InChI=1S/C6H5FO/c7-5-3-1-2-4-6(5)8/h1-4,8H
• InChI Key: HFHFGHLXUCOHLN-UHFFFAOYSA-N
• Exact Mass: 112.032442941
• Molecular Formula: C6H5FO
• Molecular Weight: 112.10
• SMILES: C1=CC=C(C(=C1)O)F
• Topological: 20.2
• Monoisotopic Mass: 112.032442941
• Physical Description: 2-fluorophenol appears as liquid or crystalline solid melting at 14-16 °C. Corrosive. Density 1.246 g / cm3.
• Boiling Point: 304 to 306 °F at 760 mmHg
• Melting Point: 61 °F
• Vapor Pressure: 1.19 [mmHg]
• Synonyms: 2-FLUOROPHENOL, 367-12-4, o-Fluorophenol, Phenol, 2-fluoro-, Phenol, o-fluoro-, 1-Fluoro-2-hydroxybenzene, CCRIS 1226, I9OW1NLY9R, EINECS 206-681-2, NSC 10294, BRN 1905112, DTXSID0047745, NSC-10294, DTXCID0027729, 4-06-00-00770 (Beilstein Handbook Reference), 4-(2-FLUOROPHENOXY)-1-BUTANOL, oFluorophenol, Phenol, ofluoro, Phenol, 2fluoro, 1Fluoro2hydroxybenzene, 206-681-2, inchi=1/c6h5fo/c7-5-3-1-2-4-6(5)8/h1-4,8, Fluorophenol, 2-fluoro-phenol, MFCD00002155, 2-fluorohydroxybenzene, Phenol, fluoro-, UNII-I9OW1NLY9R, 2-fluorophenoxy, 2-fluoro phenol, ortho-fluorophenol, Phenol, 2-fluoro-; Phenol, o-fluoro- (6CI,7CI,8CI); 2-Fluorophenol; 1-Fluoro-2-hydroxybenzene; NSC 10294; o-Fluorophenol, 2-Fluorophenol, 98%, SCHEMBL78212, SCHEMBL128264, SCHEMBL128265, SCHEMBL183542, SCHEMBL239873, SCHEMBL717094, CHEMBL224144, DTXSID001316872, NSC10294, Tox21_202915, STL264214, AKOS000118964, PS-9254, NCGC00260461-01, CAS-367-12-4, HY-41755, DB-028087, 2-Fluorophenol 1000 microg/mL in Methanol, CS-0018719, F0150, NS00041725, EN300-19239, Q27280615, F0001-1049, 1996-43-6, FP2

Application

2-Fluorophenol serves as a versatile precursor in pharmaceutical synthesis, particularly for fluorinated drug candidates targeting CNS disorders. Its electron-withdrawing fluorine enhances acidity of the phenolic OH, enabling selective etherification reactions. Researchers employ it as a directing group in metal-catalyzed C-H activation reactions, and as a monomer for specialty polymers with enhanced thermal stability. The compound also finds use in agrochemical development and as a derivatization agent in analytical chemistry.

Safety and Hazards

GHS Hazard Statements

• H226 (96.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (86.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (86.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (16.7%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (66.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (70%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (13.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (96.7%)
• Acute Tox. 4 (86.7%)
• Acute Tox. 4 (86.7%)
• Skin Irrit. 2 (66.7%)
• Eye Irrit. 2 (66.7%)
• Acute Tox. 4 (70%)
• STOT SE 3 (13.3%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.