Description

Description

2-Fluorophenetole (CAS No. 451-80-9) is a high-purity fluorinated aromatic ether with the molecular formula C₈H₉FO. Also known as 1-Ethoxy-2-fluorobenzene, this compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring an ethoxy group adjacent to a fluorine substituent on a benzene ring, enables versatile reactivity in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced intermediates.

This product is rigorously tested for purity (typically ??97% by GC) and is available in various quantities to suit laboratory-scale and industrial applications. It is supplied in amber glass bottles under inert atmosphere to ensure stability and longevity. Ideal for researchers developing novel fluorinated compounds, 2-Fluorophenetole offers excellent solubility in common organic solvents like dichloromethane, ethanol, and dimethyl sulfoxide (DMSO).

Key Features:

• CAS: 451-80-9
• Molecular Weight: 140.16 g/mol
• Boiling Point: ~185-188??C
• Density: ~1.08 g/cm³
• Storage: Store at 2-8??C in a tightly sealed container

Application

2-Fluorophenetole is widely used as a fluorinated synthon in medicinal chemistry for the development of bioactive molecules, particularly in the synthesis of kinase inhibitors and CNS-active compounds. Its electron-withdrawing fluorine enhances the reactivity of adjacent positions for further functionalization. This compound also serves as a precursor in material science for designing liquid crystals and fluorinated polymers with tailored properties. Researchers leverage its stability and compatibility with palladium-catalyzed reactions to construct complex heterocyclic frameworks.

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