Description

2-Fluoroisonicotinic acid (CAS No. 402-65-3) is a high-purity fluorinated pyridine derivative with the molecular formula C₆H₄FNO₂ and IUPAC name 2-fluoropyridine-4-carboxylic acid. This compound is a versatile building block in pharmaceutical and agrochemical research, offering unique reactivity due to the electron-withdrawing fluorine substituent. It is supplied as a white to off-white crystalline powder with ≥98% purity (HPLC), ensuring optimal performance in synthetic applications. Ideal for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for bioactive molecules. Packaged under inert gas in amber glass vials to ensure stability and longevity. Suitable for use in medicinal chemistry, material science, and as a ligand in coordination chemistry.

Properties

• CAS Number: 402-65-3
• Complexity: 140
• IUPAC Name: 2-fluoropyridine-4-carboxylic acid
• InChI: InChI=1S/C6H4FNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)
• InChI Key: JMPFWDWYGOWUFP-UHFFFAOYSA-N
• Exact Mass: 141.02260653
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.10
• SMILES: C1=CN=C(C=C1C(=O)O)F
• Topological: 50.2
• Monoisotopic Mass: 141.02260653
• Synonyms: 2-Fluoroisonicotinic acid, 402-65-3, DTXSID00323069, DTXCID00274188, 2-Fluoropyridine-4-carboxylic acid, 2-Fluoro-4-pyridinecarboxylic acid, MFCD02181194, 2-Fluoroisonicotinicacid, 4-PYRIDINECARBOXYLIC ACID, 2-FLUORO-, 2-Fluoro-isonicotinic acid, NSC402973, 2-fluoro isonicotinic acid, SCHEMBL118817, SCHEMBL23796342, SCHEMBL25382200, BCP10414, 2-fluoro-pyridine-4-carboxylic acid, BBL101850, SBB028462, STL555647, AKOS005063970, AB11490, CS-W002922, NSC-402973, PS-9023, AC-24956, SY024079, 2-Fluoro-4-pyridinecarboxylic acid, 97%, DB-024002, F0693, ST50823729, EN300-52107, F0001-3827, Z234896331

Application

2-Fluoroisonicotinic acid serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly in the development of kinase inhibitors and antibacterial agents. Its carboxylic acid functionality allows for easy derivatization into amides, esters, and other bioactive compounds. Researchers utilize this compound in metal-organic framework (MOF) synthesis due to its ability to act as a bridging ligand. The fluorine atom enhances metabolic stability in drug candidates, making it valuable for medicinal chemistry applications.

Safety and Hazards

GHS Hazard Statements

• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264+P265, P280, P305+P351+P338, and P337+P317

Hazard Classes and Categories

• Eye Irrit. 2A (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.