Description

2-Fluorobiphenyl (CAS No. 321-60-8) is a high-purity fluorinated aromatic compound with the molecular formula C₁₂H₉F and IUPAC name 1-fluoro-2-phenylbenzene. This compound is a valuable intermediate in organic synthesis, pharmaceutical research, and material science applications. It features a biphenyl core structure with a fluorine substituent at the ortho position, enhancing its reactivity and utility in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings.

Our 2-Fluorobiphenyl is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant packaging to maintain stability. Suitable for use as a reference standard, reagent, or building block in medicinal chemistry and agrochemical development. Available in quantities ranging from grams to kilograms to meet both laboratory and industrial-scale demands.

Properties

• CAS Number: 321-60-8
• Complexity: 149
• IUPAC Name: 1-fluoro-2-phenyl-benzene
• InChI: InChI=1S/C12H9F/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H
• InChI Key: KLECYOQFQXJYBC-UHFFFAOYSA-N
• Exact Mass: 172.068828449
• Molecular Formula: C12H9F
• Molecular Weight: 172.20
• SMILES: C1=CC=C(C=C1)C2=CC=CC=C2F
• Monoisotopic Mass: 172.068828449
• Physical Description: 2-fluorobiphenyl appears as colorless crystals.
• Boiling Point: 478 °F at 760 mmHg
• Melting Point: 164.3 °F
• Density: 1.2452 at 77 °F – Denser than water; will sink
• Synonyms: 2-Fluorobiphenyl, 321-60-8, 2-Fluoro-1,1′-biphenyl, o-Fluorodiphenyl, Biphenyl, 2-fluoro-, 1,1′-Biphenyl, 2-fluoro-, ortho-Fluorodiphenyl, CCRIS 1659, EINECS 206-290-7, NSC 10366, DTXSID5047744, DTXCID5027728, oFluorodiphenyl, orthoFluorodiphenyl, Biphenyl, 2fluoro, Fluorobiphenyl, 2, 2Fluoro1,1’biphenyl, 1,1’Biphenyl, 2fluoro, 206-290-7, 1-fluoro-2-phenylbenzene, 2-Fluoro-biphenyl, C12H9F, MFCD00000317, KC8Q87V4QY, NSC-10366, 2-fluoro-1-phenylbenzene, 2-Fluoro-(2′,3′,4′,5′,6′-2H5)-1,1′-biphenyl, 64420-95-7, o-Fluorobiphenyl, 2-Fluorodiphenyl, NSC10366, 1, 2-fluoro-, 2-Fluorobiphenyl, 96%, UNII-KC8Q87V4QY, SCHEMBL201614, SCHEMBL335714, SCHEMBL433551, SCHEMBL693886, SCHEMBL693994, CHEMBL122521, SCHEMBL1584225, SCHEMBL3607306, SCHEMBL4319544, SCHEMBL5116498, KLECYOQFQXJYBC-UHFFFAOYSA-, Tox21_202912, AC8710, SBB061479, AKOS006222514, CS-W017594, NCGC00260458-01, CAS-321-60-8, PS-11571, SY032390, DB-014109, 2-Fluorobiphenyl, purum, >=98.0% (GC), F0265, NS00029222, ST50406227, 10.14272/KLECYOQFQXJYBC-UHFFFAOYSA-N, 2-Fluorobiphenyl 2000 microg/mL in Cyclohexane, doi:10.14272/KLECYOQFQXJYBC-UHFFFAOYSA-N, Q63409297, InChI=1/C12H9F/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H

Application

2-Fluorobiphenyl serves as a versatile precursor in the synthesis of fluorinated liquid crystals, pharmaceutical intermediates, and specialty polymers. It is commonly employed in palladium-catalyzed cross-coupling reactions to construct complex biaryl systems. Researchers also utilize it as a model compound in environmental studies to track fluorinated aromatic pollutants. Its stability and reactivity make it ideal for probing structure-activity relationships in drug discovery.

Safety and Hazards

GHS Hazard Statements

• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (71.4%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (14.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (57.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (71.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H400 (28.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
• H410 (14.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (71.4%)
• Eye Dam. 1 (14.3%)
• Eye Irrit. 2 (57.1%)
• STOT SE 3 (71.4%)
• Aquatic Acute 1 (28.6%)
• Aquatic Chronic 1 (14.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.