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Atomfair 2-Fluorobenzylic alcohol C7H7FO CAS 446-51-5

2-Fluorobenzylic alcohol (CAS No. 446-51-5), also known as (2-fluorophenyl)methanol, is a high-purity fluorinated aromatic alcohol with the molecular formula C7H7FO . This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical applications. Its structure features a reactive benzylic hydroxyl group adjacent to a fluorine substituent, enabling diverse functionalization. Available in >98% purity (GC), it is supplied as a clear, colorless to pale-yellow liquid with a characteristic aromatic odor. Suitable for use in Grignard reactions, esterifications, and as a precursor for fluorinated fine chemicals. Store under inert gas at 2-8°C to maintain stability. Packaging options include…

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Description

2-Fluorobenzylic alcohol (CAS No. 446-51-5), also known as (2-fluorophenyl)methanol, is a high-purity fluorinated aromatic alcohol with the molecular formula C7H7FO. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical applications. Its structure features a reactive benzylic hydroxyl group adjacent to a fluorine substituent, enabling diverse functionalization. Available in >98% purity (GC), it is supplied as a clear, colorless to pale-yellow liquid with a characteristic aromatic odor. Suitable for use in Grignard reactions, esterifications, and as a precursor for fluorinated fine chemicals. Store under inert gas at 2-8°C to maintain stability. Packaging options include 1g, 5g, 25g, and custom quantities in amber glass vials with secure closures.

Properties

  • CAS Number: 446-51-5
  • Complexity: 85
  • IUPAC Name: (2-fluorophenyl)methanol
  • InChI: InChI=1S/C7H7FO/c8-7-4-2-1-3-6(7)5-9/h1-4,9H,5H2
  • InChI Key: QEHXDOJPVIHUDO-UHFFFAOYSA-N
  • Exact Mass: 126.048093005
  • Molecular Formula: C7H7FO
  • Molecular Weight: 126.13
  • SMILES: C1=CC=C(C(=C1)CO)F
  • Topological: 20.2
  • Monoisotopic Mass: 126.048093005
  • Synonyms: Benzenemethanol, 2-fluoro-, 2-Fluorobenzylic alcohol, EINECS 207-170-7, DTXSID10196241, NSC 158274, DTXCID20118732, 207-170-7, 2-Fluorobenzyl alcohol, 446-51-5, (2-Fluorophenyl)methanol, o-Fluorobenzyl alcohol, 2-Fluorobenzenemethanol, MFCD00004601, 2-Fluorobenzylalcohol, (2-fluorophenyl)methan-1-ol, NSC 158274; o-Fluorobenzyl Alcohol; 2-Fluorobenzenemethanol; (2-Fluorophenyl)methanol, (2-fluoro-phenyl)-methanol, (2-Fluorophenyl)methanol #, SCHEMBL98874, SCHEMBL98875, SCHEMBL127515, 2-Fluorobenzyl alcohol, 98%, SCHEMBL1427138, SCHEMBL1477305, SCHEMBL1968232, SCHEMBL7990691, SCHEMBL15110018, SCHEMBL18705863, QEHXDOJPVIHUDO-UHFFFAOYSA-, NSC158274, SBB064085, AKOS000119661, FF64462, NSC-158274, PS-9189, SY032653, DB-021123, CS-0156643, F0259, NS00042940, ST51028310, EN300-21298, A823338, Z104495204, InChI=1/C7H7FO/c8-7-4-2-1-3-6(7)5-9/h1-4,9H,5H2

Application

2-Fluorobenzylic alcohol serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly CNS-active compounds and antifungal agents. It is employed in asymmetric synthesis as a chiral auxiliary and as a precursor for 2-fluorobenzaldehyde derivatives. The compound’s unique electronic properties make it valuable for studying fluorine effects in medicinal chemistry structure-activity relationships.

Safety and Hazards

GHS Hazard Statements

  • H227 (25%): Combustible liquid [Warning Flammable liquids]
  • H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P210, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

  • Flam. Liq. 4 (25%)
  • Acute Tox. 4 (25%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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