Description

2-Fluorobenzoyl chloride (CAS No. 393-52-2) is a highly reactive organic compound with the molecular formula C₇H₄ClFO. This aromatic acyl chloride is a valuable building block in synthetic organic chemistry, particularly in the preparation of fluorinated benzoyl derivatives. The presence of both the fluorine substituent and the reactive acyl chloride group makes it a versatile intermediate for pharmaceuticals, agrochemicals, and specialty materials. It is supplied as a clear to pale yellow liquid with a pungent odor, typically stored under inert conditions to prevent hydrolysis. Suitable for use in peptide coupling reactions, Friedel-Crafts acylation, and other nucleophilic substitution processes. Purity is guaranteed >98% (GC) with detailed technical specifications available upon request.

Properties

• CAS Number: 393-52-2
• Complexity: 138
• IUPAC Name: 2-fluorobenzoyl chloride
• InChI: InChI=1S/C7H4ClFO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H
• InChI Key: RAAGZOYMEQDCTD-UHFFFAOYSA-N
• Exact Mass: 157.9934706
• Molecular Formula: C7H4ClFO
• Molecular Weight: 158.56
• SMILES: C1=CC=C(C(=C1)C(=O)Cl)F
• Topological: 17.1
• Monoisotopic Mass: 157.9934706
• Physical Description: 2-fluorobenzoyl chloride is a colorless liquid.
• Color/Form: Liquid
• Boiling Point: 403 °F at 760 mmHg
• Melting Point: 39 °F
• Flash Point: 180 °F
• Solubility: Decomposes
• Density: 1.304 at 68 °F – Denser than water; will sink
• Vapor Pressure: 0.46 [mmHg]
• Refractive Index: Index of refraction: 1.5365 at 20 °C/D
• Synonyms: 2-FLUOROBENZOYL CHLORIDE, o-Fluorobenzoyl chloride, Benzoyl chloride, 2-fluoro-, Benzoyl chloride, o-fluoro-, CCRIS 5914, HSDB 4261, EINECS 206-887-2, NSC 88304, UNII-Z4H017N76S, BRN 0636864, DTXSID3025330, Z4H017N76S, NSC-88304, ortho-Fluorobenzoyl chloride, DTXCID005330, RAAGZOYMEQDCTD-UHFFFAOYSA-, EC 206-887-2, 4-09-00-00951 (Beilstein Handbook Reference), 2-FLUOROBENZENECARBONYL CHLORIDE, 2-FLUOROBENZOYL CHLORIDE [HSDB], oFluorobenzoyl chloride, Benzoyl chloride, ofluoro, Benzoyl chloride, 2fluoro, O-FLUOROBENZENE CARBONYL CHLORIDE, 206-887-2, inchi=1/c7h4clfo/c8-7(10)5-3-1-2-4-6(5)9/h1-4h, raagzoymeqdctd-uhfffaoysa-n, un3094, 393-52-2, 2-fluorobenzoylchloride, MFCD00000656, 2-Fluoro-benzoyl chloride, Benzoyl chloride, fluoro-, fluorobenzoyl chloride, 2-fluorobenzoic acid chloride, 2-fluorbenzoyl chloride, 2-flurobenzoyl chloride, 2-fluoro-benzoylchloride, o-fluoro-benzoyl chloride, 2-fluoro benzoyl chloride, WLN: GVR BF, SCHEMBL60101, 2-fluoro benzoic acid chloride, 2-Fluorobenzoyl chloride, 99%, CHEMBL1606202, alpha-chloro-2-fluorobenzaldehyde, 2-fluoro-1-benzenecarbonyl chloride, NSC88304, Tox21_200637, SBB040627, STL183341, AKOS000121330, PB42721, NCGC00091418-01, NCGC00091418-02, NCGC00258191-01, CAS-393-52-2, PS-10795, F0195, NS00005399, ST50214060, EN300-19512, D70825, Q27294989, F2190-0058, o-Fluorobenzenecarbonyl chloride; o-Fluorobenzoyl chloride; 2-Fluoro-benzoic acid chloride, 2-Fluoro-benzoyl Chloride; 2-Fluorobenzenecarbonyl Chloride; o-Fluorobenzoyl Chloride; NSC 88304;

Application

2-Fluorobenzoyl chloride is widely used as a key intermediate in the synthesis of fluorinated pharmaceutical compounds, including anti-inflammatory and CNS-active drugs. It serves as a precursor for the preparation of herbicides and pesticides due to its ability to introduce fluorine into aromatic systems. Researchers also utilize this compound in materials science for modifying polymer properties and creating specialty coatings.

Safety and Hazards

GHS Hazard Statements

• H290 (66.9%): May be corrosive to metals [Warning Corrosive to Metals]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (66.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (94.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P234, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P363, P390, P403+P233, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (66.9%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (66.9%)
• STOT SE 3 (94.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.