Description

2-Fluoroaniline (CAS No. 348-54-9) is a high-purity fluorinated aromatic amine with the molecular formula C₆H₆FN. This compound, also known by its IUPAC name 2-fluoroaniline, is a versatile intermediate in organic synthesis and pharmaceutical research. It features a fluorine substituent at the ortho position of the aniline ring, enhancing its reactivity for electrophilic substitution and cross-coupling reactions. Our product is rigorously tested to ensure ≥98% purity (GC), making it ideal for sensitive applications. Available in quantities from grams to kilograms, it is supplied in amber glass bottles or sealed containers to ensure stability and longevity. Suitable for use in HPLC, GC-MS, and NMR analysis, this reagent is a must-have for researchers in medicinal chemistry and material science.

Properties

• CAS Number: 348-54-9
• Complexity: 74.9
• IUPAC Name: 2-fluoroaniline
• InChI: InChI=1S/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
• InChI Key: FTZQXOJYPFINKJ-UHFFFAOYSA-N
• Exact Mass: 111.048427358
• Molecular Formula: C6H6FN
• Molecular Weight: 111.12
• SMILES: C1=CC=C(C(=C1)N)F
• Topological: 26
• Monoisotopic Mass: 111.048427358
• Physical Description: 2-fluoroaniline is a clear liquid with a mild sweet odor. Sinks in and mixes slowly with water.
• Boiling Point: 347 °F at 760 mmHg
• Melting Point: -19.3 °F
• Flash Point: 140 °F
• Density: 1.1513 at 69.8 °F – Denser than water; will sink
• Vapor Pressure: 1.0 [mmHg]
• Dissociation Constants: 3.2
• Synonyms: 2-FLUOROANILINE, o-Fluoroaniline, Benzenamine, 2-fluoro-, Aniline, o-fluoro-, 2-fluorophenylamine, Aniline, 2-fluoro-, CHEBI:27526, SE32ZK6617, EINECS 206-478-9, NSC 10299, NSC-10299, UNII-SE32ZK6617, AI3-52644, DTXSID8059843, UN 2941, oFluoroaniline, Aniline, ofluoro, 2Fluorobenzenamine, 2Fluorophenylamine, 1Amino2fluorobenzene, Benzenamine, 2fluoro, Aniline, ofluoro (8CI), Aniline, o-fluoro-(8CI), DTXCID1038905, 206-478-9, ftzqxojypfinkj-uhfffaoysa-n, inchi=1/c6h6fn/c7-5-3-1-2-4-6(5)8/h1-4h,8h, un2941, 348-54-9, 1-Amino-2-fluorobenzene, 2-Fluorobenzenamine, 2-Fluoro-phenylamine, o-aminofluorobenzene, MFCD00007642, CHEMBL195328, 2-fluoro-benzenamine, 2fluoroaniline, 2-flouroaniline, 2-fluoro aniline, 2-fluoro-aniline, 1lgw, 2-Fluoroaniline-, Ortho-fluoroaniline, 2-fluorobenzeneamine, 2-fluorobenzenaminium, (2-fluorophenyl)amine, 1,2-fluorobenzenamine, (2-fluorophenyl)-amine, bmse000724, 2-Fluoroaniline, >=99%, SCHEMBL33295, BIDD:GT0093, SCHEMBL423990, SCHEMBL443906, SCHEMBL654711, SCHEMBL1028569, SCHEMBL1029912, SCHEMBL2959812, CS-M2715, NSC10299, STR00771, BDBM50167958, SBB040472, STK802386, AKOS000118879, CCG-302491, DB02403, FF15645, 1AN, o-Fluoroaniline; 1-Amino-2-fluorobenzene, PD008363, DB-028080, A6120, F0032, NS00041421, ST45255293, EN300-19550, AG-617/02198032, o-Fluoroaniline [UN2941] [Keep away from food], Q27093404, F2190-0425, Z104474198

Application

2-Fluoroaniline serves as a key building block in the synthesis of fluorinated pharmaceuticals, agrochemicals, and dyes. Its electron-withdrawing fluorine group facilitates the preparation of heterocyclic compounds and active pharmaceutical ingredients (APIs). Researchers utilize it in palladium-catalyzed coupling reactions to create complex aromatic structures. It is also employed in the development of liquid crystals and advanced polymer materials.

Safety and Hazards

GHS Hazard Statements

• H226 (46%): Flammable liquid and vapor [Warning Flammable liquids]
• H301+H311+H331 (51.6%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H301 (53.2%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (46.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (53.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (46%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (52.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (88.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (11.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (53.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (35.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H341 (52.4%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H351 (52.4%): Suspected of causing cancer [Warning Carcinogenicity]
• H372 (52.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
• H400 (53.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

Precautionary Statements

• P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (46%)
• Acute Tox. 3 (53.2%)
• Acute Tox. 4 (46.8%)
• Acute Tox. 3 (53.2%)
• Skin Irrit. 2 (46%)
• Skin Sens. 1 (52.4%)
• Eye Dam. 1 (88.1%)
• Eye Irrit. 2 (11.9%)
• Acute Tox. 3 (53.2%)
• STOT SE 3 (35.7%)
• Muta. 2 (52.4%)
• Carc. 2 (52.4%)
• STOT RE 1 (52.4%)
• Aquatic Acute 1 (53.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.